Purified anti-FMRP Antibody
- 产品名称：
- Purified anti-FMRP Antibody
- 产品类别：
- 抗体
- 产品编号：
- 859001
- 产品应用：
- 859001
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human recombinant protein fragment: amino acids 36-279
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2801227 (BioLegend Cat. No. 859001) AB_2801228 (BioLegend Cat. No. 859002)
- Structure
- FMRP is a 632 amino acid protein with a molecular mass of ~71 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed with higher expression levels in brain tissue.
Cellular distribution: Plasma membrane, nucleus, and cytosol.
- Function
- FMRP has been reported to be involved in synaptic plasticity, dendritic spine maturation as well as synapse formation. FMRP may play a role in gene silencing by acting as translation regulator.
- Interaction
- FMRP interacts with the RNA binding proteins such as FXR1P, FXR2P and 82-FIP. FMRP can also interact with the cytoplasmic proteins CYFIP1 and CYFIP2 which then interacts with eIF4E thus linking FMRP to the RhoGTPase signaling pathway.
- Ligand/Receptor
- mGluR stimulation leads to increased FMRP expression.
- Cell Type
- Neurons
- Biology Area
- Neurodegeneration, Protein Synthesis
- Molecular Family
- Postsynaptic proteins, Presynaptic proteins
- Antigen References
-
- Qiu S, et al. 2018. Mol Brain. 11(1):54
- Sunamura N, et al. 2018. Sci Rep. 8(1):11585
- Linder B, et al. 2008. Hum Mol Genet. 17(20):3236-46
- Gholizadeh S, et al. 2014. Neuropsychopharmacology. 39:3100.
- Gene ID
- 2332 View all products for this Gene ID
- UniProt
- View information about FMRP on UniProt.org
