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Purified anti-human CD352 (NTB-A) Antibody
产品名称:
Purified anti-human CD352 (NTB-A) Antibody
产品类别:
抗体
产品编号:
317202
产品应用:
317202
[价格]
规格 价格 库存
100µg ¥ 1488 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant extracellular domain of NTB-A
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Stim -?Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: stimulation of NTB-A in a redirected lysis assay and blocking of NTB-A function3. The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 317211 & 317212). Co-stimulation of cells with CD3 antibodies and clone NT-7 has been shown to induce activation rather than blocking function of these cells3.

Application References

(PubMed link indicates BioLegend citation)
  1. Messmer B, et al. 2006. J. Immunol. 176:4646. (FC)
  2. Ward J, et al. 2007. Blood 110:1207. (FC) PubMed
  3. Uzana R, et al. 2012. J. Immunol. 188:632. (Block) PubMed
  4. Baglaenko Y, et al. 2017. J. Immunol. 198: 3949. (Stim)
Product Citations
  1. Uzana R, et al. 2012. J Immunol. 188:632. PubMed
  2. Elias S, et al. 2020. Haematologica. . PubMed
  3. Ward J, et al. 2007. Blood. 110:1207. PubMed
RRID
AB_571931 (BioLegend Cat. No. 317202)

Antigen Details

Structure
Type I transmembrane tyrosine-phosphorylated glycoprotein, CD2/CD150 subfamily, 60 kD
Distribution

NK cells, T cells, B cells

Function
CD28 independent T cell costimulation, induction of NK cell cytotoxicity, regulation of B cell tolerance
Ligand/Receptor
NTBA
Cell Type
B cells, NK cells, T cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Bottino C, et al. 2001. J. Exp. Med. 194:235.
2. Valdez PA, et al. 2004. J. Bio. Chem. 279:18662.
3. Flaig RM, et al. 2004. J. Immunol. 172:6524.
4. Falco M, et al. 2004. Eur. J. Immunol. 34:1663.
5. Kumar KR, et al. 2006. Science 312:1665.

Gene ID
114836 View all products for this Gene ID
UniProt
View information about CD352 on UniProt.org

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