PE anti-human HLA-DRB1 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1980	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

L-cell transfectants HLA-DRB1*0401(11th IHW 8115), CFA

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application Notes

Clone NFLD.D2 recognizes a shared epitope (DRB1*70-74:QKRAA and QRRAA) of HLA_DRB1*04.

Application References (PubMed link indicates BioLegend citation)

Wicks I, et al. 1997. Ann. Rheum Dis. 56:135 (FC)
Patil NS, et al. 2001. J. Immunol. 12:7157 (FC)
Drover S, et al. 1998. Hum. Immunol. 59:77 (FA)

RRID

AB_2563518 (BioLegend Cat. No. 362303) AB_2563519 (BioLegend Cat. No. 362304)

Antigen Details

Structure: MHC class II cell surface receptor, 30 kD
Distribution: APCs
Function: Presentation of the peptide to T cells leads to activation or suppression of the immune system, which eventually leads to the immune response.
Interaction: CD4⁺ T cells
Cell Type: Antigen-presenting cells, B cells, Dendritic cells
Biology Area: Immunology, Innate Immunity
Molecular Family: MHC Antigens
Antigen References: 1. Scally SW, et al.?2013. J. Exp. Med. 210:2569.
2. Balnyte R, et al. 2013.?BMC Neurol. 13:77.
3. Ranasinghe S, et al. 2013.?Nat. Med. 19:930.
4. Foo JN, et al. 2013.?Am. J. Hum. Genet. 93:167.
5. Balandraud N,?et al. 2013.?PLoS One. 8:e64108.
6. Sutton VR, et al. 1988.?Hum. Immunol. 22:123.
7. Stunz LL, et al. 1989.?J. Immunol. 143:3081.
Gene ID: 3123 View all products for this Gene ID
UniProt: View information about HLA-DRB1 on UniProt.org

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