Brilliant Violet 605™ anti-human CD279 (PD-1-上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 2508	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

YT cell line.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).

Preparation

The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 605? under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Brilliant Violet 605? excites at 405 nm and emits at 603 nm. The bandpass filter 610/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 605? is a trademark of Sirigen Group Ltd.

Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.

Excitation Laser

Violet Laser (405 nm)

Application Notes

Additional reported applications (for the relevant formats of this clone) include: immunofluorescence staining.

We recommend using our Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB) (Cat. No. 929501).

Application References (PubMed link indicates BioLegend citation)

Roncador G, et al. 2007. Haematologica 92:1059.
Nam-Cha SH, et al. 2008. Am. J. Surg. Pathol. 32:1252.
Rodriguez-Pinilla SM, et al. 2009. Am. J. Surg. Pathol. 33:81.

RRID

AB_2721544 (BioLegend Cat. No. 367425) AB_2721545 (BioLegend Cat. No. 367426)

Antigen Details

Structure: 55 kD type I transmembrane protein.
Distribution: Transiently expressed on CD4^- and CD8^- thymocytes, upregulated in thymocytes and splenic T and B lymphocytes, and is expressed on activated myeloid cells.
Function: Signaling, co-stimulation (co-inhibition), immunoglobulin superfamily.
Interaction: SHP-1 and SHP-2.
Ligand/Receptor: PD-L1 (CD274) and PD-L2 (CD273).
Cell Type: Thymocytes, T cells, B cells, Tregs
Biology Area: Immunology, Cancer Biomarkers, Inhibitory Molecules
Molecular Family: CD Molecules, Immune Checkpoint Receptors
Antigen References: 1. Francisco LM, Sage PT, and Sharpe AH. 2010. Immunological Rev. 236:219.
Gene ID: 5133 View all products for this Gene ID
UniProt: View information about CD279 on UniProt.org

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