Purified anti-Laforin Antibody
- 产品名称：
- Purified anti-Laforin Antibody
- 产品类别：
- 抗体
- 产品编号：
- 858001
- 产品应用：
- 858001
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Fusion protein corresponding to amino acids 1-331 (full-length) of human Laforin
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 2.5 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2783481 (BioLegend Cat. No. 858001) AB_2783482 (BioLegend Cat. No. 858002)
- Structure
- Lafora protein is a 331 amino acids tyrosine phosphatase consisting of an N-terminal carbohydrate-binding modue (CBM) and a C-terminal dual-specific phosphatase domain (DSP).
- Distribution
-
Tissue distribution: Laforin is ubiquitously expressed in all tissues, particularly abundant in skeleton muscle, heart, and brain.
Cellular source: Depending on the isoform, this protein can be either in cytosolic or nuclear.
- Function
- Glycogen metabolism, glycogen dephosphorylation, ubiquitin proteasome system function, protein clearnce
- Interaction
- Interactions: Malin, AMP-activated protein kinase (AMPK)Cellular targets: the muscle isoform of glycogen synthase, PTG, protein phosphatase type 1 (PP1), neuronatin
- Ligand/Receptor
- Laforin was shown to be regulated by the glycogen storage in cell, but the mechanism is unclear.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
- Molecular Family
- Protein Kinases/Phosphatase, Enzymes and Regulators
- Antigen References
-
- Gentry MS, et al. 2013. FEBS J.?280(2):525-37.
- Sankhala RS, et al. 2015. J Biol chem. 290(8):4552-9.
- Singh PK, et al. 2012. Mol Cell Biol. 32(3):652-63.
- Mittal S, et al. 2007. Hum Mol Genet. 16(7):753-62.
- Tagliabracci VS, et al. 2007. Proc. Natl. Acad. Sci U S A. 104(49):19262-6.
- Gene ID
- 7957 View all products for this Gene ID
- UniProt
- View information about Laforin on UniProt.org
