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首页 > 抗体蛋白 > 抗体
Pacific Blue™ anti-mouse CD11c Antibody
产品名称：
Pacific Blue™ anti-mouse CD11c Antibody
产品类别：
抗体
产品编号：
117321
产品应用：
117321
[价格]
规格 价格 库存
25µg ￥ 1128 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse spleen dendritic cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography, and conjugated with Pacific Blue? under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The CD11c antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume. It is highly recommended that the reagent be titrated for optimal performance for each application.

* Pacific Blue? has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue? conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.


Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

View full statement regarding label licenses
Excitation Laser
Violet Laser (405 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation3, immunohistochemical staining of acetone-fixed frozen sections3, immunofluorescence microscopy5, 9 (Alexa Fluor? 488 conjugated N418 was used for IHC in frozen sections10), and spatial biology (IBEX)22,23.

Application References

(PubMed link indicates BioLegend citation)
  1. Granucci F, et al. 1997. J. Immunol. 159:1794.
  2. Stokes RW, et al. 1998. J. Immunol. 160:5514.
  3. Metlay JP, et al. 1990. J. Exp. Med. 171:1753. (IHC, IP)
  4. Ma XT, et al. 2006. Cancer Research 66:1169.
  5. Chin RK, et al. 2006. J. Immunol. 177:290. (IF)
  6. Cervantes-Barragan L, et al. 2007. Blood 109:1131. (FC) PubMed
  7. Turnquist HR, et al. 2007. J. Immunol. 178:7018. (FC) PubMed
  8. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  9. You Y, et al. 2009. J. Immunol. 182:7343. (IF) PubMed
  10. Roland CL, et al. 2009. Mol. Cancer Res. 8:1761. (IHC, FC) PubMed
  11. Wikstrom M, et al.2006. J. Immunol. 177:913. PubMed
  12. Pericolini E, et al. 2008. J. Leukocyte Biol. 83:1286. PubMed
  13. Randall LM, et al. 2008. Infect. Immun.76:3312. PubMed
  14. Fahlen-Yrild L, et al. 2009. J. Immunol. 183:5032. PubMed
  15. Osterholzer JJ, et al. 2009. J. Immunol. 183:8044. PubMed
  16. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  17. Eisenach PA, et al. 2010. J Cell Sci. 123:4182. PubMed
  18. Leppin K, et al. 2014. Invest. Ophthalmol. Vis. Sci. 55:3603. PubMed
  19. Sakai F, et al. 2014. PLoS One. 9:105370. PubMed
  20. Gibbins JD, et al. 2014. Blood. 124:2953. PubMed
  21. White CE, et al. 2015. J Immunol. 194:697. PubMed
  22. Lu X, et al. 2015. J Immunol. 194:2011. PubMed
  23. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  24. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Serra-Hassoun M, et al. 2014. J Immunol. 193:1504. PubMed
  2. Boyd DF, et al. 2020. Nature. 587:466. PubMed
  3. Jankovic D, et al. 2013. J Exp Med. 210:1899. PubMed
  4. Schneider C, et al. 2018. Cell. 174:271. PubMed
  5. Zas?ona Z, et al. 2014. J Immunol. 193:4245. PubMed
  6. Gon?alves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  7. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  8. Menzel L, et al. 2021. Cell Rep. 37:109878. PubMed
  9. Eastman A, et al. 2016. J Immunol . 194: 5999-6010. PubMed
  10. Zhao X, et al. 2022. Cell Biosci. 12:3. PubMed
  11. Yang Y, et al. 2021. Nat Commun. 12:525. PubMed
  12. Kitano M, et al. 2016. Proc Natl Acad Sci U S A. 113: 1044 - 1049. PubMed
  13. Ni P, et al. 2014. J Immunol . 193:1778. PubMed
  14. Billi AC, et al. 2019. JCI Insight. 4:8. PubMed
  15. Katakam A, et al. 2015. Proc Natl Acad Sci U S A. 112: 14664 - 14669. PubMed
  16. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  17. Kohn M, et al. 2021. Front Immunol. 580594:12. PubMed
  18. Emg?rd J, et al. 2018. Immunity. 143:419. PubMed
  19. Saravia J, et al. 2015. PLoS Pathog. 11: e1005217. PubMed
  20. Leonard JD et al. 2017. Immunity. 47(1):107-117 . PubMed
  21. Krishnamurthy B, et al. 2015. Diabetes. 64: 3229-3238. PubMed
  22. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  23. Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed
  24. Huang L, et al. 2018. Exp Neurol. 300:41. PubMed
  25. Yeung F, et al. 2020. Cell Host & Microbe. 27(5):809-822. PubMed
  26. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  27. O'Leary CE, et al. 2021. Curr Protoc. 1:e77. PubMed
  28. Wen T, et al. 2014. J Immunol. 192:5481. PubMed
  29. Onishi M, et al. 2015. J Immunol. 194:2673. PubMed
  30. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  31. Asadi Shahmirzadi A, et al. 2020. Cell Metabolism. 32(3):447-456.e6. PubMed
  32. Wawrzyniak M, et al. 2021. Pharmacol Res Perspect. 9:e00837. PubMed
  33. Chao JL, et al. 2021. Cell Rep Med. 2:100399. PubMed
  34. Wu Y, et al. 2015. J Immunol. 195: 2612-2623. PubMed
  35. Darlyuk-Saadon I, et al. 2021. FEBS J. 288:3978. PubMed
  36. Malenica I, et al. 2021. Nat Commun. 12:5209. PubMed
  37. Zhang X, et al. 2021. Front Pharmacol. 12:706748. PubMed
  38. Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
  39. Mak'Anyengo R, et al. 2018. JCI Insight. 3:e96322. PubMed
  40. Wang Y, et al. 2021. Nature. 599:308. PubMed
  41. Kolb R, et al. 2016. Nat Commun. 7:13007. PubMed
  42. Keller S, et al. 2014. J Control Release. 191:24. PubMed
  43. Richardson M, et al. 2014. PLoS Negl Trop Dis. 8:2825. PubMed
  44. Yá?ez A et al. 2017. Immunity. 47(5):890-902 . PubMed
RRID
AB_755987 (BioLegend Cat. No. 117321) AB_755988 (BioLegend Cat. No. 117322)

Antigen Details

Structure
Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution

Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells

Function
Cellular adhesion
Ligand/Receptor
iC3b, fibrinogen
Cell Type
Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lopez-Rodriguez C, et al. 1996. J. Immunol. 156:3780.

Gene ID
16411 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

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