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Alexa Fluor® 700 anti-mouse CD11c Antibody
产品名称：
Alexa Fluor® 700 anti-mouse CD11c Antibody
产品类别：
抗体
产品编号：
117319
产品应用：
117319
[价格]
规格 价格 库存
25µg ￥ 1128 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse spleen dendritic cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 700 under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is highly recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor? 700 has a maximum emission of 719 nm when it is excited at 633nm / 635nm. Prior to using Alexa Fluor? 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.


Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

View full statement regarding label licenses
Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation3, immunohistochemical staining of acetone-fixed frozen sections3, immunofluorescence microscopy5, 9 (Alexa Fluor? 488 conjugated N418 was used for IHC in frozen sections10), and spatial biology (IBEX)22,23.

Application References

(PubMed link indicates BioLegend citation)
  1. Granucci F, et al. 1997. J. Immunol. 159:1794.
  2. Stokes RW, et al. 1998. J. Immunol. 160:5514.
  3. Metlay JP, et al. 1990. J. Exp. Med. 171:1753. (IHC, IP)
  4. Ma XT, et al. 2006. Cancer Research 66:1169.
  5. Chin RK, et al. 2006. J. Immunol. 177:290. (IF)
  6. Cervantes-Barragan L, et al. 2007. Blood 109:1131. (FC) PubMed
  7. Turnquist HR, et al. 2007. J. Immunol. 178:7018. (FC) PubMed
  8. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  9. You Y, et al. 2009. J. Immunol. 182:7343. (IF) PubMed
  10. Roland CL, et al. 2009. Mol. Cancer Res. 8:1761. (IHC, FC) PubMed
  11. Wikstrom M, et al.2006. J. Immunol. 177:913. PubMed
  12. Pericolini E, et al. 2008. J. Leukocyte Biol. 83:1286. PubMed
  13. Randall LM, et al. 2008. Infect. Immun.76:3312. PubMed
  14. Fahlen-Yrild L, et al. 2009. J. Immunol. 183:5032. PubMed
  15. Osterholzer JJ, et al. 2009. J. Immunol. 183:8044. PubMed
  16. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  17. Eisenach PA, et al. 2010. J Cell Sci. 123:4182. PubMed
  18. Leppin K, et al. 2014. Invest. Ophthalmol. Vis. Sci. 55:3603. PubMed
  19. Sakai F, et al. 2014. PLoS One. 9:105370. PubMed
  20. Gibbins JD, et al. 2014. Blood. 124:2953. PubMed
  21. White CE, et al. 2015. J Immunol. 194:697. PubMed
  22. Lu X, et al. 2015. J Immunol. 194:2011. PubMed
  23. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  24. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Yang N, et al. 2022. NPJ Vaccines. 7:120. PubMed
  2. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  3. Wiesner DL, et al. 2020. Cell Host Microbe. 614:27. PubMed
  4. Garcia-Fabiani MB, et al. 2020. Methods Enzymol. 632:369. PubMed
  5. Hickey A, et al. 2021. Front Microbiol. 12:653587. PubMed
  6. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  7. Hreha TN, et al. 2020. Front Immunol. 1.597916667. PubMed
  8. Atibalentja D, et al. 2011. J Immunol. 186:1421. PubMed
  9. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  10. An YA et al. 2017. eLife. 6 pii: e24071. PubMed
  11. Panciera T, et al. 2016. Cell Stem Cell. 19:725-737. PubMed
  12. Krementsov DN, et al. 2018. Front Immunol. 9:1622. PubMed
  13. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  14. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  15. Sarkar J, et al. 2013. Invest Ophthalmol Vis Sci . 54:5920. PubMed
  16. Wu H, et al. 2019. Autophagy. :1. PubMed
  17. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  18. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  19. Doron I, et al. 2021. Cell. 184(4):1017-1031.e14. PubMed
  20. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  21. Nadafi R, et al. 2020. Cell Reports. 30(12):4110-4123. PubMed
  22. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  23. Panea C, et al. 2021. Commun Biol. 4:913. PubMed
  24. Hassan AO, et al. 2021. Cell Reports. 36(4):109452. PubMed
  25. Mishra BB, et al. 2017. Nat Microbiol. 2:17072. PubMed
  26. Fran?a TT, et al. 2021. JCI Insight. 6:. PubMed
  27. Lim CX, et al. 2020. Cell Rep. 3793:30. PubMed
  28. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  29. Bell CR, et al. 2022. Nat Commun. 13:2063. PubMed
  30. Vogel A, et al. 2022. Cell Rep. 38:110420. PubMed
  31. Rustenhoven J, et al. 2021. Cell. 184(4):1000-1016.e27. PubMed
  32. Grayczyk JP et al. 2017. Cell host & microbe. 22(5):678-687 . PubMed
  33. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  34. Han P, et al. 2020. Sci Adv. 6:eaaz1580. PubMed
  35. Dourcy M, et al. 2020. Mucosal Immunol. 13:799. PubMed
  36. Goldberg EL, et al. 2021. Cell Metabolism. :. PubMed
  37. Li X, et al. 2018. Cell Host Microbe. 24:847. PubMed
  38. Chirivi RGS, et al. 2020. Cell Mol Immunol. . PubMed
  39. Dammeijer F, et al. 2020. Cancer Cell. 38(5):685-700.e8. PubMed
  40. Sadiq BA, et al. 2020. Current Protocols in Immunology. 131(1):e115. PubMed
  41. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  42. Zysset D, et al. 2016. Nat Commun. 7:13151. PubMed
RRID
AB_528735 (BioLegend Cat. No. 117319) AB_528736 (BioLegend Cat. No. 117320)

Antigen Details

Structure
Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution

Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells

Function
Cellular adhesion
Ligand/Receptor
iC3b, fibrinogen
Cell Type
Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lopez-Rodriguez C, et al. 1996. J. Immunol. 156:3780.

Gene ID
16411 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

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