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Alexa Fluor® 488 anti-mouse CD11c Antibody
产品名称：
Alexa Fluor® 488 anti-mouse CD11c Antibody
产品类别：
抗体
产品编号：
117313
产品应用：
117313
[价格]
规格 价格 库存
25µg ￥ 1212 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse spleen dendritic cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 488 under optimal conditions.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?L volume. It is recommended that the reagent be titrated for optimal performance for other applications.

* Alexa Fluor? 488 has a maximum emission of 519 nm when it is excited at 488 nm.

?


Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

View full statement regarding label licenses
Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation3, immunohistochemical staining of acetone-fixed frozen sections3, immunofluorescence microscopy5, 9 (Alexa Fluor? 488 conjugated N418 was used for IHC in frozen sections10), and spatial biology (IBEX)22,23.

Application References

(PubMed link indicates BioLegend citation)
  1. Granucci F, et al. 1997. J. Immunol. 159:1794.
  2. Stokes RW, et al. 1998. J. Immunol. 160:5514.
  3. Metlay JP, et al. 1990. J. Exp. Med. 171:1753. (IHC, IP)
  4. Ma XT, et al. 2006. Cancer Research 66:1169.
  5. Chin RK, et al. 2006. J. Immunol. 177:290. (IF)
  6. Cervantes-Barragan L, et al. 2007. Blood 109:1131. (FC) PubMed
  7. Turnquist HR, et al. 2007. J. Immunol. 178:7018. (FC) PubMed
  8. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  9. You Y, et al. 2009. J. Immunol. 182:7343. (IF) PubMed
  10. Roland CL, et al. 2009. Mol. Cancer Res. 8:1761. (IHC, FC) PubMed
  11. Wikstrom M, et al.2006. J. Immunol. 177:913. PubMed
  12. Pericolini E, et al. 2008. J. Leukocyte Biol. 83:1286. PubMed
  13. Randall LM, et al. 2008. Infect. Immun.76:3312. PubMed
  14. Fahlen-Yrild L, et al. 2009. J. Immunol. 183:5032. PubMed
  15. Osterholzer JJ, et al. 2009. J. Immunol. 183:8044. PubMed
  16. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  17. Eisenach PA, et al. 2010. J Cell Sci. 123:4182. PubMed
  18. Leppin K, et al. 2014. Invest. Ophthalmol. Vis. Sci. 55:3603. PubMed
  19. Sakai F, et al. 2014. PLoS One. 9:105370. PubMed
  20. Gibbins JD, et al. 2014. Blood. 124:2953. PubMed
  21. White CE, et al. 2015. J Immunol. 194:697. PubMed
  22. Lu X, et al. 2015. J Immunol. 194:2011. PubMed
  23. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  24. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Chen G, et al. 2016. J Immunol. 196: 1810 - 1821. PubMed
  2. Kawabe T, et al. 2020. Nat Commun. 2.795833333. PubMed
  3. You Y, et al. 2009. J Immunol. 182:7343. PubMed
  4. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  5. Mason HD, et al. 2021. JCI Insight. 6:e149229. PubMed
  6. Coleby R, et al. 2021. Clin Exp Rheumatol. :39. PubMed
  7. Hu HJ, et al. 2020. Cell Death Dis. 1.168055556. PubMed
  8. Mogilenko DA, et al. 2020. Immunity. 54(1):99-115.e12. PubMed
  9. Lino AC et al. 2018. Immunity. 49(1):120-133 . PubMed
  10. Ooi JD, et al. 2019. Nat Commun. 10:3392. PubMed
  11. De Vlaeminck Y, et al. 2020. Cancers (Basel). 12:. PubMed
  12. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  13. Liu W, et al. 2021. Cell Mol Immunol. 18:2660. PubMed
  14. Zhang S, et al. 2021. Cell. 184(8):2151-2166.e16. PubMed
  15. Hays C, et al. 2020. eLife. 8:e48772.. PubMed
  16. Li S, et al. 2021. Ann Transl Med. 9:1644. PubMed
  17. Khandelwal P, et al. 2013. PLoS One. 8:64193. PubMed
  18. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  19. Roland C, et al. 2009. PLoS One. 4:e7669. PubMed
  20. Yang H, et al. 2015. Cancer Res . 75: 3812-3822. PubMed
  21. Mohan J, et al. 2013. J Exp Med. 210:2403. PubMed
  22. Bhattacherjee A, et al. 2019. Commun Biol. 2:450. PubMed
  23. Wan W, et al. 2013. Cardiovasc Res. 97:580. PubMed
  24. Wei SC, et al. 2020. Cancer Discov. . PubMed
  25. Maston LD, et al. 2017. Am J Physiol Lung Cell Mol Physiol. 312:L609. PubMed
  26. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  27. Wang S, et al. 2018. Biomaterials. 187:28:00. PubMed
  28. Roland C, et al. 2009. Mol Cancer Ther. 1.55625. PubMed
  29. Jiang H, et al. 2016. J Immunol. 197: 2880 - 2890. PubMed
  30. Xue N, et al. 2017. Sci Rep. 7:39011. PubMed
  31. Dey S, et al. 2020. J Immunother Cancer. 8:. PubMed
  32. Collins N, et al. 2016. Nat Commun. 7:11514. PubMed
  33. Napp J, et al. 2019. Theranostics. 4.754861111. PubMed
  34. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  35. Hamaidi I, et al. 2020. Cell Metabolism. 32(3):420-436.e12. PubMed
  36. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  37. Liu P, et al. 2020. Mol Cell. 748:77. PubMed
  38. Miyajima M,et al. 2017. Nat Immunol.. 10.1038/ni.3867. PubMed
  39. Rosato PC, et al. 2019. Nat Commun. 10:567. PubMed
  40. Foster G, et al. 2015. J Immunol. 195: 5380 - 5392. PubMed
  41. Lee GR, et al. 2021. JCI Insight. 6:. PubMed
  42. Yates J, et al. 2013. J Immunol. 191:1240. PubMed
  43. Riedelberger M, et al. 2020. Cell Host & Microbe. 27(3):454-466. PubMed
  44. Morrissey MA, et al. 2018. Elife. 7:e36688. PubMed
RRID
AB_492849 (BioLegend Cat. No. 117313) AB_389306 (BioLegend Cat. No. 117311)

Antigen Details

Structure
Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution

Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells

Function
Cellular adhesion
Ligand/Receptor
iC3b, fibrinogen
Cell Type
Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lopez-Rodriguez C, et al. 1996. J. Immunol. 156:3780.

Gene ID
16411 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

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