Purified anti-Arl13b Antibody
- 产品名称：
- Purified anti-Arl13b Antibody
- 产品类别：
- 抗体
- 产品编号：
- 857601
- 产品应用：
- 857601
- Verified Reactivity
- Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Fusion protein corresponding to amino acids 208-427 (C-terminus) of mouse Arl13b.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5.0 - 10 ?g per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2801215 (BioLegend Cat. No. 857601) AB_2801216 (BioLegend Cat. No. 857602)
- Structure
- Murine Arl13b is a 427 amino acid protein with a molecular mass of 48 kD.
- Distribution
-
Tissue distribution: Neuroepithelial cells, developing radial glial cells, and fibroblasts.
Cellular distribution: Localized in primary cilium, usually at apical cell soma domains of cells.
- Function
- Ciliogenesis in multiple organs; regulation of radial glial cell polarity and scaffold; control of microtube-based, ciliary axoneme structure; endocytic recycling and trafficking.
- Interaction
- Arl13b interacts with tubulin, actin cytoskeleton, and SUMO-conjugating enzyme UBC-9.
- Ligand/Receptor
- Sonic hedgehog signaling ligand like Smoothened and Patched; ciliary sensory receptors
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology
- Molecular Family
- Postsynaptic proteins
- Antigen References
-
- Barral D.C. et al. 2012. Proc Natl Acad Sci U S A. 109(52), 21354-9.
- Caspary, T.et al. 2007.Developmental Cell. 12, 767–778.
- Higginbotham, H. et al. 2013. Nat. Neurosci. 16(8):1000-7.
- Ivanova, A.A. et al. 2017. J Biol Chem. 292(26), 11091–11108.
- Li Y. et al. 2012. J. Cell Biol. 199(4), 589-98.
- Gene ID
- 68146 View all products for this Gene ID
- UniProt
- View information about Arl13b on UniProt.org
