Purified anti-HCN4 Antibody
- 产品名称:
- Purified anti-HCN4 Antibody
- 产品类别:
- 抗体
- 产品编号:
- 857001
- 产品应用:
- 857001
- Verified Reactivity
- Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Fusion protein corresponding to amino acids 1021-1110 (cytoplasmic C-terminus) of human HCN4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.5 - 10 ?g per ml.?For immunohistochemistry on formalin-fixed paraffin-embedded tissues, a concentration range of 5.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2783467 (BioLegend Cat. No. 857001) AB_2783468 (BioLegend Cat. No. 857002)
- Structure
- HCN4 is a 1,186 amino acid protein with a molecular mass of 127 kD.
- Distribution
-
Tissue distribution: Brain, heart, adrenal gland, and testis.
Cellular distribution: Membrane.
- Function
- HCN4 generates inward current If in the heart and Ih in the brain, and modulates intrinsic neuronal excitability and synaptic integrity.
- Interaction
- HCN4 interacts with other HCN subunits (HCN1-3) to form a functional channel.
- Cell Type
- Neurons
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology
- Molecular Family
- Presynaptic proteins
- Antigen References
-
- Kelmendi, B. et al. 2011. Neurosci Lett. 496(3): 195–199.
- Stieber, J. et al. 2003. Proc Natl Acad Sci U S A. 100(25):15235-40.
- Xu, X. et al. 2010. J Biol Chem. 285(47):37082-91.
- Gene ID
- 330953 View all products for this Gene ID 59266 View all products for this Gene ID
- UniProt
- View information about HCN4 on UniProt.org