PE/Cyanine7 anti-mouse CD41 Antibody
- 产品名称：
- PE/Cyanine7 anti-mouse CD41 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 133915
- 产品应用：
- 133915
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse platelets
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume.? It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for in vivo studies (Cat. No.?133939).
- Additional Product Notes
- BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
- Application References
(PubMed link indicates BioLegend citation) -
- Nieswandt B, et al. 1999. Blood 94:684.
- Teeling JL, et al. 2001. Blood 98:1095.
- Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
- Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
- Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
- van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
- Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
- Product Citations
-
- Yamaguchi A, et al. 2021. Genes Cells. 26:782. PubMed
- Fujii T, et al. 2015. Proc Natl Acad Sci U S A. 112: 12800 - 12805. PubMed
- Lutzmann M, et al. 2019. Cell Rep. 28:2851. PubMed
- van Erp EA, et al. 2019. Viruses. 0.811111111. PubMed
- Patenaude J, Perreault C 2016. J Immunol. 196: 4760 - 4770. PubMed
- Li D, et al. 2021. Mol Med Rep. 23:. PubMed
- , et al. 2021. Eur J Immunol. 51:2708. PubMed
- Scialdone A, et al. 2016. Nature. 535:289-293. PubMed
- Gentek R, et al. 2018. Immunity. 48:1160. PubMed
- Brait VH, et al. 2019. Circ Res. 124:279. PubMed
- Spevak CC, et al. 2020. Cell Stem Cell. 26(5):755-765. PubMed
- Nakagawa MM, et al. 2018. Cell Rep. 25:2094. PubMed
- RRID
- AB_11125173 (BioLegend Cat. No. 133915) AB_11124102 (BioLegend Cat. No. 133916)
- Structure
- A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
- Distribution
-
Platelets, megakaryocytes, and hematopoietic progenitors
- Function
- Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
- Ligand/Receptor
- Fibrinogen, fibronectin, von Willebrand factor, thrombin
- Cell Type
- Hematopoietic stem and progenitors, Megakaryocytes, Platelets
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359.
- Gene ID
- 16399 View all products for this Gene ID
- UniProt
- View information about CD41 on UniProt.org
