PE anti-mouse CD41 Antibody
- 产品名称：
- PE anti-mouse CD41 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 133905
- 产品应用：
- 133905
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse platelets
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for in vivo studies (Cat. No.?133939).
- Application References
(PubMed link indicates BioLegend citation) -
- Nieswandt B, et al. 1999. Blood 94:684.
- Teeling JL, et al. 2001. Blood 98:1095.
- Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
- Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
- Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
- van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
- Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
- Product Citations
-
- Sandovici I, et al. 2022. Dev Cell. 57:63. PubMed
- Ho YH, et al. 2019. Cell Stem Cell. 25:407. PubMed
- Lang J, et al. 2020. Nat Commun. 11:1338. PubMed
- Luchsinger LL, et al. 2020. Cell Stem Cell. 25(2):225-240. PubMed
- Machata S, et al. 2021. Front Immunol. 11:565869. PubMed
- Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
- Wiley CD, et al. 2019. Cell Rep. 28:3329. PubMed
- Li Q, et al. 2019. Neuron. 101:207. PubMed
- Matsushita Y, et al. 2021. J Bone Miner Res. 36:1145. PubMed
- Cummings H, et al. 2013. J Immunol. 191:5807. PubMed
- Meng S, et al. 2022. Exp Anim. . PubMed
- Iturri L, et al. 2021. Immunity. . PubMed
- Wong J, et al. 2015. Elife. 3: 07839. PubMed
- Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
- Yeung AK, et al. 2020. Blood Adv. 4:6204. PubMed
- Ma L, et al. 2015. Blood. 126: 247 - 256. PubMed
- Liu Z, et al. 2016. J Biol Chem. 291: 1441 - 1447. PubMed
- Stivala S, et al. 2019. J Clin Invest. 130:1596. PubMed
- Wang JD, et al. 2021. Cancers (Basel). :13. PubMed
- Elahi S, et al. 2020. Stem Cell Res. 43:101710. PubMed
- Yan R, et al. 2021. Cell Death Dis. 12:955. PubMed
- Jiang Y, et al. 2021. Cell Death Differ. 28:3009. PubMed
- Sevin M, et al. 2018. Nat Commun. 9:1431. PubMed
- Bikorimana E, et al. 2014. J Vis Exp. 92: 52022. PubMed
- He H, et al. 2020. Sci Adv. 6:00. PubMed
- Wang T, et al. 2022. Int J Nanomedicine. 17:2191. PubMed
- McVey MJ, et al. 2017. Am J Physiol Lung Cell Mol Physiol. 312:L625. PubMed
- Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
- RRID
- AB_2265179 (BioLegend Cat. No. 133905) AB_2129745 (BioLegend Cat. No. 133906)
- Structure
- A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
- Distribution
-
Platelets, megakaryocytes, and hematopoietic progenitors
- Function
- Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
- Ligand/Receptor
- Fibrinogen, fibronectin, von Willebrand factor, thrombin
- Cell Type
- Hematopoietic stem and progenitors, Megakaryocytes, Platelets
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359.
- Gene ID
- 16399 View all products for this Gene ID
- UniProt
- View information about CD41 on UniProt.org
