FITC anti-mouse CD41 Antibody
- 产品名称：
- FITC anti-mouse CD41 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 133903
- 产品应用：
- 133903
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse platelets
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for in vivo studies (Cat. No.?133939).
- Application References
(PubMed link indicates BioLegend citation) -
- Nieswandt B, et al. 1999. Blood 94:684.
- Teeling JL, et al. 2001. Blood 98:1095.
- Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
- Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
- Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
- van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
- Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
- Product Citations
-
- Laura C Burzynski et al. 2019. Immunity. 50(4):1033-1042 . PubMed
- Moreau J, et al. 2015. Blood. 126: 1184-1192. PubMed
- G?tz P, et al. 2022. Int J Mol Sci. 23:. PubMed
- Mitroulis I et al. 2018. Cell. 172(1-2):147-161 . PubMed
- Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
- Wong P 2011. Development. 138:2833. PubMed
- Li H, et al. 2021. Nat Commun. 12:2773. PubMed
- Plein A, et al. 2018. Nature. 562:223. PubMed
- Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
- Pan N, et al. 2021. Mar Drugs. 20:. PubMed
- Long A, et al. 2016. Toxicol Pathol. 44: 998 - 1012. PubMed
- Lin J, et al. 2021. Mol Med. 27:149. PubMed
- Greenwald AC, et al. 2019. J Exp Med. 216:215. PubMed
- Comazzetto S et al. 2018. Cell stem cell. 24(3):477-486 . PubMed
- Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
- Rani GF, et al. 2021. Blood Adv. 5:1627. PubMed
- La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
- Oka Y, et al. 2020. Sci Adv. 6:. PubMed
- Comoglio F, et al. 2018. Genome Res. 10.1101/gr.227272.117. PubMed
- Malara A, et al. 2017. J Biol Chem. 292(8):3239-3251. PubMed
- Trinh HKT, et al. 2019. J Cell Mol Med. 23:3441. PubMed
- Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
- Cornelius DC, et al. 2020. PLoS One. 15:e0234039. PubMed
- Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
- Lam J, et al. 2018. Nat Commun. 9:2418. PubMed
- RRID
- AB_1626237 (BioLegend Cat. No. 133903) AB_2129746 (BioLegend Cat. No. 133904)
- Structure
- A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
- Distribution
-
Platelets, megakaryocytes, and hematopoietic progenitors
- Function
- Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
- Ligand/Receptor
- Fibrinogen, fibronectin, von Willebrand factor, thrombin
- Cell Type
- Hematopoietic stem and progenitors, Megakaryocytes, Platelets
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359.
- Gene ID
- 16399 View all products for this Gene ID
- UniProt
- View information about CD41 on UniProt.org
