APC anti-mouse CD41 Antibody
- 产品名称：
- APC anti-mouse CD41 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 133913
- 产品应用：
- 133913
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse platelets
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for in vivo studies (Cat. No.?133939).
- Application References
(PubMed link indicates BioLegend citation) -
- Nieswandt B, et al. 1999. Blood 94:684.
- Teeling JL, et al. 2001. Blood 98:1095.
- Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
- Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
- Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
- van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
- Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
- Product Citations
-
- Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
- Upadhaya S, et al. 2020. Cell Stem Cell. 27(2):336-345.e4. PubMed
- Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
- Fujino T, et al. 2021. Nat Commun. 12:1826. PubMed
- Nakamura T, et al. 2022. Thromb Res. 209:80. PubMed
- Wang W, et al. 2016. Circ Cardiovasc Genet. 9: 213 - 222. PubMed
- Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
- McCabe A, et al. 2020. STAR Protocols. 33(7):2294-305. PubMed
- Kobayashi H, et al. 2020. STAR Protoc. 1:100078. PubMed
- Yeung AK, et al. 2020. Blood Adv. 4:6204. PubMed
- Cordeiro O, et al. 2016. PLoS One. 11: 0151848. PubMed
- Sung PS, et al. 2019. Nat Commun. 10:2402. PubMed
- Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
- Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
- Zhang Q, et al. 2016. Sci Transl Med. 8: 349ra101. PubMed
- Parker KR, et al. 2020. Cell. 183(1):126-142.e17. PubMed
- Yan R, et al. 2021. Cell Death Dis. 12:955. PubMed
- Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
- Tang C, et al. 2021. Theranostics. 11:9791. PubMed
- Pagan JD, et al. 2018. Cell. 172:564. PubMed
- Kobayashi H, et al. 2020. Cell Reports. 28(1):145-158.e9.. PubMed
- de Laval B, et al. 2020. Cell Stem Cell. 26(5):657-674. PubMed
- Da Q, et al. 2018. Microcirculation. 25:e12457. PubMed
- Siddique SM, et al. 2019. Sci Rep. 9:13977. PubMed
- Chen W, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2028. PubMed
- La Salvia S, et al. 2020. Am J Physiol Renal Physiol. 319:F868. PubMed
- Kniewallner KM, et al. 2020. Front Neurosci. 14:129. PubMed
- Crescente M, et al. 2020. FASEB J. 34:10027. PubMed
- Li H, et al. 2020. J Cell Mol Med. 24:3504. PubMed
- Han P, et al. 2020. Sci Adv. 6:eaaz1580. PubMed
- Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
- Wuescher LM, et al. 2019. Res Pract Thromb Haemost. 3:704. PubMed
- Chen W, et al. 2022. J Thromb Haemost. 20:1451. PubMed
- RRID
- AB_11126751 (BioLegend Cat. No. 133913) AB_11125581 (BioLegend Cat. No. 133914)
- Structure
- A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
- Distribution
-
Platelets, megakaryocytes, and hematopoietic progenitors
- Function
- Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
- Ligand/Receptor
- Fibrinogen, fibronectin, von Willebrand factor, thrombin
- Cell Type
- Hematopoietic stem and progenitors, Megakaryocytes, Platelets
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359.
- Gene ID
- 16399 View all products for this Gene ID
- UniProt
- View information about CD41 on UniProt.org
