Ultra-LEAF™ Purified anti-mouse IL-23 (p19)
- 产品名称：
- Ultra-LEAF™ Purified anti-mouse IL-23 (p19)
- 产品类别：
- 抗体
- 产品编号：
- 513807
- 产品应用：
- 513807
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Mouse p19 C-terminal peptide
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
ELISA-C, ICC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization of mouse IL-23 (5 ng/ml) in mouse splenocytes.
- Application Notes
ELISA Capture: The purified MMP19B2 antibody is useful as a capture antibody for a sandwich ELISA assay, when used in conjunction with the biotinylated C17.8 antibody as detection antibody.
- Application References
(PubMed link indicates BioLegend citation) -
- Keswani T, et al. 2014. Exp Parasitol. 141:82. PubMed
- RRID
- AB_2801103 (BioLegend Cat. No. 513807) AB_2801104 (BioLegend Cat. No. 513808)
- Structure
- Member of the IL-12 cytokine family, heterodimeric cytokine composed of p40 subunit shared with IL-12 and a specific p19 subunit
- Distribution
-
Secreted by activated dendritic cells and macrophages.
- Function
- Upregulated in viral infections, increased in psoriatic lesions and promotes immunity to mycobacteria.
- Ligand/Receptor
- IL-23 receptor (β1 subunit of IL-12 receptor and IL-23-specific subunit)
- Bioactivity
- Enhances IFN-γ secretion by memory (CD45RO) T cells and induces unique Th subset (designated Th-17) secreting IL-17.
- Cell Type
- Dendritic cells, Macrophages
- Biology Area
- Immunology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Oppmann B, et al. 2000. Immunity 13:715.
2. Parham C, et al. 2002. J. Immunol. 168:5448.
3. Aggarwal S, et al. 2003. J. Biol. Chem. 278:1910.
4. Verreck FA, et al. 2004. Proc. Natl. Acad. Sci. USA 101:4560.
5. Lee E, et al. 2004. J. Exp. Med. 199:125.
- Gene ID
- 83430 View all products for this Gene ID
- UniProt
- View information about IL-23 on UniProt.org
