Ultra-LEAF™ Purified anti-mouse IL-9 Antibod-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 2844	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Baculovirus-expressed, recombinant mouse IL-9

Formulation

0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.

Preparation

The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.

Concentration

The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.

Application

FA -?Quality tested
Neut -?Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by functional assay. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: neutralization⁴. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for neutralization of mouse IL-9 bioactivity. MM9C1 is able to neutralize mouse IL-9 induced proliferation of M-07e cells with an IC₅₀ 50 ng/mL.

Application References (PubMed link indicates BioLegend citation)

Abrams J. 1995. Curr. Prot. Immunol. John Wiley and Sons, New York. Unit 6.20.
Renauld J, et al. 1995. J. Leuk. Biol. 57:353.
Sitkauskiene B, et al. 2005. Respir. Res. 6:33.
Gounni AS, et. al. 2004. J. Immunol. 173:2771. (Neut)

RRID

AB_2876741 (BioLegend Cat. No. 659505) AB_2876741 (BioLegend Cat. No. 659506)

Antigen Details

Structure: Cytokine
Distribution: Th2 cells and mast cells, activated Th9, Th17, and Tregs.
Function: Upregulated by IL-1 after TCR activation, also upregulated by TNF-α; downregulated by antibodies to IL-2.
Interaction: T helper cells, Th9, Th17, Treg, human airway smooth muscle cells.
Ligand/Receptor: Mouse IL-9R
Cell Type: Th17, Th2, Tregs
Biology Area: Cell Biology, Immunology
Molecular Family: Cytokines/Chemokines
Antigen References: 1. Goswami R. and Kaplan MH. 2011. J. Immunol. 186:3283.
2. Kaiko GE, and Foster PS. 2011. Curr. Opin. Allergy Clin. Immunol. 11:39.
3. Townsend JM, et al. 2000. Immunity. 13:573.
4. Mock BA,?et al. 1990. Immunogenetics. 31:265.
5. Tan C,?et al. 2010. J. Immunol. 185:6795.
6. Jager A,?et al. 2009. J. Immunol. 183:7169.
Gene ID: 16198 View all products for this Gene ID
UniProt: View information about IL-9 on UniProt.org

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