APC anti-human CD272 (BTLA) Antibody
- 产品名称：
- APC anti-human CD272 (BTLA) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 344509
- 产品应用：
- 344509
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1848 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- African Green
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human BTLA transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: inhibition of T cell proliferation and cytokine production1. Clone MIH26 has agonistic activity on BTLA, resulting in the inhibition of activation.
The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for use in in vitro and in vivo biofunctional assays.
- Application References
(PubMed link indicates BioLegend citation) -
- Otsuki N, et al. 2006. Biochem. Bioph. Res. Co. 344:1121.
- Okano M, et al. 2008. Clin. Exp. Allergy 38:1891.
- Product Citations
-
- Piancone F, et al. 2016. Sci Rep. 6:29699. PubMed
- Bourdely P, et al. 2020. Immunity. 53(2):335-352. PubMed
- Li X, et al. 2019. Front Oncol. 1.115277778. PubMed
- Anzengruber F, et al. 2019. Leuk Lymphoma. N/A. PubMed
- Spodzieja M, et al. 2017. PLoS One. 12(6):e0179201. PubMed
- Zhang JA, et al. 2020. Front Immunol. 11:518. PubMed
- Abd Hamid M et al. 2019. Cancer Immunol Res. 7(8):1293-1306 . PubMed
- Hwang HJ, et al. 2021. Immun Inflamm Dis. 9:274. PubMed
- RRID
- AB_10612942 (BioLegend Cat. No. 344509) AB_10613101 (BioLegend Cat. No. 344510)
- Structure
- Ig superfamily, with similar structure to CTLA-4 and PD-1
- Distribution
-
B cells and T lymphocytes, NK cells and dendritic cells
- Function
- Negative regulation of T cell activation, proliferation and cytokine production
- Ligand/Receptor
- HVEM
- Cell Type
- B cells, Dendritic cells, NK cells, T cells, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- CD Molecules
- Antigen References
-
1. Watanabe N, et al. 2003. Nat. Immunol. 4:670.
2. Sun Y, et al. 2009. J. Immunol. 183:1946.
3. Gonzalez LC, et al. 2005. P. Natl. Acad. Sci. USA 102:1116.
- Gene ID
- 151888 View all products for this Gene ID
- UniProt
- View information about CD272 on UniProt.org
