Purified anti-human CD274 (B7-H1, PD-L1) Antibody
- 产品名称：
- Purified anti-human CD274 (B7-H1, PD-L1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 393602
- 产品应用：
- 393602
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human PD-L1-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2749895 (BioLegend Cat. No. 393602)
- Structure
- Type 1 transmembrane protein, member of the B7 family, 40 kD.
- Distribution
-
T cells, B cells, NK cells, monocytes/macrophages, granulocytes and dendritic cells
- Function
- CD274 is involved in the costimulatory signal, essential for T lymphocyte proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-CD1-independent manner. Its interaction with PD-1-CD1 inhibits T-cell proliferation and cytokine production.
- Ligand/Receptor
- PD-1 (CD279), B7-1 (CD80).
- Cell Type
- T cells, B cells, NK cells, Monocytes, Macrophages, Granulocytes, Dendritic cells
- Biology Area
- Immunology, Cancer Biomarkers, Costimulatory Molecules
- Molecular Family
- Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors
- Antigen References
-
- Khan AR, et al. 2015. Nat Commun. 6:5997
- Kiyasu J, et al. 2015. Blood. 126:2193
- Herold M, et al. 2015. J Immunol. 195:3584
- Buddhisa S, et al. 2015. J Immunol. 194:4413
- Gene ID
- 29126 View all products for this Gene ID
- UniProt
- View information about CD274 on UniProt.org
