Purified anti-human Notch 4 Antibody
- 产品名称：
- Purified anti-human Notch 4 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 349002
- 产品应用：
- 349002
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Notch 4-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Kim H, et al. 2015. Cytotherapy. 17:579. PubMed
- Product Citations
-
- Kim H, et al. 2015. Cytotherapy. . PubMed
- RRID
- AB_10612568 (BioLegend Cat. No. 349002)
- Structure
- Transmembrane protein. Extracellular domain forms a heterodimer and contains 29 epidermal growth factor-like repeats and 3 Lin/Notch Glp repeats. The intracellular domain contains 5 CDC10/Ankryn repeats, 1 proline, glutamate, serine, threonine-rich motif,
- Distribution
- Heart, lung, placenta, liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow, and fetal liver.
- Function
- Controls many cell developmental processes such as differentiation, proliferation and apoptosis. Plays a role in vascular, renal, and hepatic development.
- Interaction
- MAML1, MAML2 and MAML3, CBF-1, Smad3, and Smad4
- Ligand/Receptor
- Jagged1, Jagged2, Delta1, Delta3, and Delta4
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Transcription Factors
- Antigen References
-
1. Katoh M and Katoh M. 2007. Int. J. Oncol. 30:247.
2. Kerbel RS. 2008. N. Engl. J. Med. 358:2039.
3. Chen VC, et al. 2008. Nat. Biotechnol. 26:1169.
4. Emuss V. 2009. PLoS Pathog. 5:e1000616.
5. Harrison H, et al. 2010. Cancer Res. 70:709.
- Gene ID
- 929 View all products for this Gene ID
- UniProt
- View information about Notch 4 on UniProt.org
