Purified anti-human Delta-like protein 4 (DLL4) An
- 产品名称：
- Purified anti-human Delta-like protein 4 (DLL4) An
- 产品类别：
- 抗体
- 产品编号：
- 346501
- 产品应用：
- 346501
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human DLL4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
- Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications for the relevant formats include: blocking of DLL4 binding to Notch 1 and Notch 4.
- Application References
(PubMed link indicates BioLegend citation) -
- Yamanda S, et al. 2009. Blood 113:3631.
- RRID
- AB_1967111 (BioLegend Cat. No. 346501) AB_1967137 (BioLegend Cat. No. 346502)
- Structure
- Type I transmembrane protein whose extracellular domain contains a DSL domain and eight tandem EGF repeats
- Distribution
- Vascular endothelium, neural epithelium, adrenal cortex, spleen, and lymph nodes; highly expressed in some types of bladder, breast and renal carcinomas
- Function
- Vascular development and homeostasis
- Ligand/Receptor
- Notch 1 and Notch 4
- Cell Type
- Epithelial cells, Endothelial cells, Dendritic cells, Tregs
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules
- Antigen References
-
1. Beck RC, et al. 2009. Biol Blood Marrow Transplant. 15:1026.
2. Mazella J, et al. 2008. Endocrinology. 149:15.
3. Noguera-Troise I, et al. 2006. Nature 444:1032.
4. Sugimoto A, et al. 2006. Exp Hematol. 34:424.
5. Liu ZJ, et al. 2003. Mol Cell Biol. 23:14.
- Gene ID
- 54567 View all products for this Gene ID
- UniProt
- View information about DLL4 on UniProt.org
