Purified anti-human Delta-like protein 1 (DLL1) An
- 产品名称：
- Purified anti-human Delta-like protein 1 (DLL1) An
- 产品类别：
- 抗体
- 产品编号：
- 346402
- 产品应用：
- 346402
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- hu DLL1-hu IgG Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2092810 (BioLegend Cat. No. 346402)
- Structure
- Type I transmembrane protein, the mature form consist of a 528 aa extracellular domain which contains a DSL domain and eight tandem EGF repeats, a 23 aa transmembranal region and a 155 aa cytoplasmic domain. After Notch binding, a consecutive cleavage of
- Distribution
- Expressed in heart and pancreas, with lower expression in brain and muscle. Is expressed in the cortico-medullary region of the thymus and in the fetal and adult human hematopoietic tissues. In addition, is expressed transiently during gastrulation and early organogenesis in the fetus.
- Function
- Regulates the differentiation and survival of a variety of cell types including B, T and dendritic cells, conditional deletion of Dll1 postnatally completely abrogates MZ B-cell development
- Ligand/Receptor
- Notch receptors
- Cell Type
- Dendritic cells, Tregs
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules
- Antigen References
-
1. Fu L, et al. 2009. Anticancer Res. 29:3967
2. Zhou J, et al. 2009. Immunity 30:845
3. Radke AL, et al. 2009. Blood 113:3092
4. Six EM, et al. 2004. J. Biol. Chem. 279:55818
5. Hozumi K, et al. 2004. Nat Immunol. 2004 5:638
- Gene ID
- 28514 View all products for this Gene ID
- UniProt
- View information about DLL1 on UniProt.org
