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首页 > 抗体蛋白 > 抗体
Purified anti-mouse CD62L Antibody
产品名称：
Purified anti-mouse CD62L Antibody
产品类别：
抗体
产品编号：
104402
产品应用：
104402
[价格]
规格 价格 库存
500µg ￥ 1656 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C3H/eb mouse B lymphoma 38C-13
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF?, IHC-F - Verified
IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1-3, complement-dependent cytotoxicity4, in vivo and in vitro blocking of adhesion1-3,5, and immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections6. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 104457-104462).

Application References

(PubMed link indicates BioLegend citation)
  1. Gallatin WM, et al. 1983. Nature 304:30. (IP, Block)
  2. Siegelman MH, et al. 1990. Cell 61:611. (IP, Block)
  3. Lewinsohn DM, et al. 1987. J. Immunol. 138:4313. (IP, Block)
  4. Iwabuchi K, et al. 1991. Immunobiology 182:161. (CMCD)
  5. Pizcueta P, et al. 1994. Am. J. Pathol. 145:461.
  6. Reichert RA, et al. 1986. J. Immunol. 136:3535. (IHC, FC)
  7. Olver S, et al. 2006. Cancer Res. 66:571.
  8. Fukushima A, et al. 2006. Invest. Ophthalmol. Vis. Sci. 47:657. PubMed
  9. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  10. Chappaz S, et al. 2007. Blood doi:10.1182/blood-2007-02-074245. (FC) PubMed
  11. Lee JW, et al. 2006. Nature Immunol. 8:181.
  12. Shigeta A, et al. 2008. Blood 112:4915 (FC) PubMed
  13. de Vries VC, et al. 2009. Am. J. Transplant. 9:2270 PubMed
Product Citations
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  4. Guo R, et al. 2020. Cell Res. 30:21. PubMed
  5. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  6. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  7. Ban YH, et al. 2017. Cell Rep. 2.6375. PubMed
  8. Yang J, et al. 2020. Front Immunol. 10:3048. PubMed
  9. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  10. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  11. Carpenter SM, et al. 2017. PLoS Pathog. 13:e1006704. PubMed
  12. Arimura K, et al. 2017. Mucosal Immunol. 1.08125. PubMed
  13. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  14. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  15. Li W, et al. 2020. J Clin Invest. 130:6718. PubMed
  16. Muhammad F, et al. 2020. Front Immunol. 975:11. PubMed
  17. Morabito KM, et al. 2017. Mucosal Immunol. 0.795138889. PubMed
  18. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  19. Doorduijn EM, et al. 2018. Front Immunol. 0.416666667. PubMed
  20. Sun H, et al. 2018. J Cell Biol. 217:1453. PubMed
  21. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  22. Oba T, et al. 2021. J Immunother Cancer. 9:. PubMed
  23. Xie D, et al. 2020. Eur J Immunol. 50:1729. PubMed
  24. Tan Z, et al. 2020. Mol Ther Oncolytics. 16:302. PubMed
  25. Sato Y, et al. 2021. BMC Cancer. 21:1222. PubMed
  26. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  27. Abboud G, et al. 2018. Front Immunol. 9:1973. PubMed
  28. Hsiao CC, et al. 2021. Cells. 10:. PubMed
  29. Kim SJ, et al. 2017. Nat Immunol. 18:1016. PubMed
  30. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  31. Lorsung RM, et al. 2020. Front Bioeng Biotechnol. 0.9375. PubMed
  32. Park GY, et al. 2020. Immune Netw. e43:20. PubMed
  33. Gil-Pulido J, et al. 2017. PLoS One.. 10.1371/journal.pone.0181947. PubMed
  34. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  35. Liu M, et al. 2018. Diabetologia. 61:2333. PubMed
  36. Kenna T, et al. 2008. Blood. 111:2091. PubMed
  37. Daley D, et al. 2017. Nat Med. 23:556. PubMed
  38. King IL, et al. 2017. Mucosal Immunol. 10:1160. PubMed
  39. Yates K, et al. 2018. Proc Natl Acad Sci U S A. 115:2162. PubMed
  40. Oyarce K, et al. 2018. Front Immunol. 9:112. PubMed
  41. Florek M, et al. 2015. PLoS One. 10: 0145763. PubMed
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  44. Flietner E, et al. 2022. Sci Rep. 12:10616. PubMed
  45. Kakaradov B, et al. 2017. Nat Immunol. 18:422. PubMed
  46. Rosenbaum M, et al. 2019. Nat Commun. 2.05. PubMed
  47. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
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  51. Cui X, et al. 2017. J Immunol. 199:4066. PubMed
  52. Cané S, et al. 2021. J Immunother Cancer. 9:. PubMed
  53. Jun JC, et al. 2017. PLoS One. 12:e0180688. PubMed
  54. Karuppuchamy T, et al. 2020. Inflamm Bowel Dis. 216:26. PubMed
  55. Olver S, et al. 2005. Cancer Res. 66:571. PubMed
  56. Richards KA, et al. 2018. Front Immunol. 0.829861111. PubMed
  57. Englezou PC, et al. 2018. Mol Ther Nucleic Acids. 12:118. PubMed
  58. Winter C, et al. 2018. Cell Metab. 28:175. PubMed
  59. Zhang J, et al. 2019. Onco Targets Ther. 12:4985. PubMed
  60. Managlia E, et al. 2019. Am J Pathol. 189:604. PubMed
  61. K?stele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  62. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
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RRID
AB_313089 (BioLegend Cat. No. 104402)

Antigen Details

Structure
Selectin, 95 kD (neutrophils) or 74 kD (lymphocytes)
Distribution

Subsets of B and T cells, monocytes, granulocytes, subset of NK cells

Function
Lymphocyte homing to HEV, rolling on activated endothelium
Ligand/Receptor
CD34, GlyCAM-1, MAdCAM-1
Cell Type
B cells, Granulocytes, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Kishimoto TK, et al. 1990. P. Natl. Acad. Sci. USA 87:2244.
3. Tedder TF, et al. 1995. J. Exp. Med. 181:2259.

Gene ID
20343 View all products for this Gene ID
UniProt
View information about CD62L on UniProt.org

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