APC anti-human CD141 (Thrombomodulin) Antibody
- 产品名称：
- APC anti-human CD141 (Thrombomodulin) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 344106
- 产品应用：
- 344106
[价格]
| 规格 |
价格 |
库存 |
| 100tests |
￥ 3768 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Product Citations
-
- Montes de Oca M, et al. 2016. Cell Rep. 17:399-412. PubMed
- de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
- Longman R, et al. 2014. J Exp Med. 211:1571. PubMed
- Kubo M, et al. 2018. Oncol Rep. 39:417. PubMed
- ?lvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
- Weisberg SP, et al. 2020. Cell Reports. 29(12):3916-3932.e5.. PubMed
- Woodberry T, et al. 2017. Infect Immun. 85:e00986. PubMed
- Autenrieth S, et al. 2015. Clin Transl Immunology. 4:50. PubMed
- Adhikaree J, et al. 2019. Oncoimmunology. 8:1593803. PubMed
- RRID
- AB_10900238 (BioLegend Cat. No. 344105) AB_10899578 (BioLegend Cat. No. 344106)
- Structure
- Single chain, type I membrane glycoprotein, 75 kD
- Distribution
-
Macrophages, monocytes, subset of myeloid dendritic cells, vascular endothelial cells, keratinocytes
- Function
- After thrombin binding, CD141 activates protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated.
- Interaction
- Protein C, Thrombin-activatable fibrinolysis inhibitor (TAFI), Platelet factor 4 (PF4)
- Ligand/Receptor
- Thrombin
- Cell Type
- Dendritic cells, Endothelial cells, Macrophages, Monocytes
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Suzuki K, et al. 1987. EMBO J. 6:1891.
2. Esmon CT, et al. 1989. J. Biol. Chem. 264:4743.
3. Delvaeye M, et al. 2009. N. Engl. J. Med. 361:345.
4. Shi CS, et al. 2008. Blood 112:3661.
5. Chen LC, et al. 2009. J. Infect. 58:368.
- Gene ID
- 7056 View all products for this Gene ID
- UniProt
- View information about CD141 on UniProt.org
