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首页 > 抗体蛋白 > 抗体
PE/Cyanine5 anti-mouse/human CD11b Antibody
产品名称：
PE/Cyanine5 anti-mouse/human CD11b Antibody
产品类别：
抗体
产品编号：
101209
产品应用：
101209
[价格]
规格 价格 库存
25µg ￥ 924 1

产品详情

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine5 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone M1/70 has been verified for?immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) (Cat. No. 101248).

Additional Product Notes
BioLegend is in the process of converting the name PE/Cy5 to PE/Cyanine5. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine5 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  36. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Ponomarev E, et al. 2006. J Immunol. 176:1402. PubMed
  2. Okajima T, et al. 2021. Front Immunol. 12:738041. PubMed
  3. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  4. Nita A, et al. 2021. Cell Reports. 34(5):108688. PubMed
  5. Marques RM, et al. 2021. Cell Death Differ. 28:3140. PubMed
  6. S?ndergaard E, et al. 2020. Cell Reports. 29(9):2756-2769.e6.. PubMed
  7. Kinder JM, et al. 2020. Cell Reports. 31(12):107784.. PubMed
  8. Wei H, et al. 2020. Cell Death Dis. 11:290. PubMed
  9. Liu Y, et al. 2021. Haematologica. Online ahead of print. PubMed
  10. Godbersen-Palmer C, et al. 2020. J Immunol. 204:2973. PubMed
  11. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  12. Dave K et al. 2017. eLife. 6 pii: e23382. PubMed
  13. Ma YV, et al. 2021. MAbs. 13:2003281. PubMed
  14. Wang F, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:257. PubMed
  15. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  16. Khoramian Tusi B, et al. 2018. Exp Hematol. 60:21. PubMed
  17. Di Genua C, et al. 2020. Cancer Cell. 37(5):690-704.e8.. PubMed
  18. Amouzegar A, et al. 2017. Stem Cells. 10.1002/stem.2611. PubMed
  19. Mamedov MR, et al. 2018. Immunity. 48:350. PubMed
  20. Heger L, et al. 2018. Front Immunol. 9:744. PubMed
  21. Cervera–Carrascon V, et al. 2020. Oncoimmunology. 9:1761229. PubMed
  22. Yankova E, et al. 2021. Nature. 593:597. PubMed
  23. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  24. Yang C, et al. 2021. J Invest Dermatol. 810:141. PubMed
  25. Dawar S, et al. 2016. Cell Death Dis. 7:e2509. PubMed
  26. Booth CAG, et al. 2018. Cancer Cell. 33:274. PubMed
  27. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  28. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  29. Wang SK, et al. 2021. JCI Insight. 6: . PubMed
  30. Ghandhi SA, et al. 2019. Sci Rep. 9:19434. PubMed
  31. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  32. Severance AL, et al. 2022. iScience. 25:104400. PubMed
  33. Zervantonakis I, et al. 2012. Proc Natl Acad Sci U S A. 109:13515. PubMed
  34. Perry JL, et al. 2020. ACS Nano. 5.583333333. PubMed
  35. Hsu M, et al. 2022. Nat Immunol. 23:581. PubMed
  36. Wilkes MC, et al. 2020. Nat Commun. 2.780555556. PubMed
  37. Nowak W, et al. 2020. EBioMedicine. 50:290-305.. PubMed
  38. Omatsu Y, et al. 2022. Nat Commun. 13:2654. PubMed
  39. Tzelepis K, et al. 2018. Nat Commun. 9:5378. PubMed
  40. Kaiser T, et al. 2019. Eneuro. 6. PubMed
  41. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  42. Azzoni E, et al. 2021. Cell Rep. 37:110103. PubMed
  43. Koide S, et al. 2022. iScience. 25:103603. PubMed
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  47. Porrello A, et al. 2018. Nat Commun. 9:1988. PubMed
  48. Yu H, et al. 2015. PLoS One. 10: 0143001. PubMed
  49. S?wen P et al. 2018. eLife. 7 pii: e41258. PubMed
  50. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  51. Chen D, et al. 2021. JCI Insight. 6:. PubMed
  52. Rowe R, et al. 2016. J Exp Med. 213: 1497 - 1512. PubMed
  53. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  54. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  55. Morales J, et al. 2014. J Leukoc Biol. 95:643. PubMed
  56. Shao TY et al. 2019. Cell host & microbe. 25(3):404-417 . PubMed
RRID
AB_312792 (BioLegend Cat. No. 101209) AB_312793 (BioLegend Cat. No. 101210)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

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