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首页 > 抗体蛋白 > 抗体
Pacific Blue™ anti-mouse/human CD11b Antibod
产品名称：
Pacific Blue™ anti-mouse/human CD11b Antibod
产品类别：
抗体
产品编号：
101223
产品应用：
101223
[价格]
规格 价格 库存
25µg ￥ 1128 1

产品详情

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with Pacific Blue? under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume. It is highly recommended that the reagent be titrated for optimal performance for each application.

* Pacific Blue? has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue? conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.


Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

View full statement regarding label licenses
Excitation Laser
Violet Laser (405 nm)
Application Notes

Clone M1/70 has been verified for?immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) (Cat. No. 101248).

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  36. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Kretschmer I, et al. 2016. J Biol Chem. 291: 4091 - 4106. PubMed
  2. Zaman R, et al. 2021. Immunity. :. PubMed
  3. Hou X, et al. 2020. Cell Reports. 28(1):172-189.e7.. PubMed
  4. Arora H, et al. 2019. Immunity. 50:418. PubMed
  5. Tomida S, et al. 2019. Sci Rep. 9:10751. PubMed
  6. Kim JS, et al. 2020. Immunity. 54(1):176-190.e7. PubMed
  7. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  8. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  9. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  10. Sharma A, et al. 2014. J Infect Dis. . PubMed
  11. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  12. Schneider C, et al. 2018. Cell. 174:271. PubMed
  13. Shen S, et al. 2018. Pain Med. 19:686. PubMed
  14. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  15. Rodriguez-García A, et al. 2021. Nat Commun. 12:877. PubMed
  16. Hewitson JP, et al. 2020. J Immunol. 204:2949. PubMed
  17. Castiello MC, et al. 2020. J Allergy Clin Immunol. . PubMed
  18. Lino AC et al. 2018. Immunity. 49(1):120-133 . PubMed
  19. Zhu H, et al. 2018. Elife. 7:. PubMed
  20. Ren S, et al. 2019. Oncol Rep. 41:1509. PubMed
  21. Silver AC, et al. 2018. Heliyon. 4:e00579. PubMed
  22. Rao E, et al. 2021. Sci Immunol. 6:. PubMed
  23. Cheng G, et al. 2021. iScience. 24:102673. PubMed
  24. Tang Y, et al. 2020. Front Immunol. 11:585918. PubMed
  25. Janelsins B, et al. 2013. Blood. 121:2923. PubMed
  26. Uhl J, et al. 2019. J Cell Commun Signal. 13:209. PubMed
  27. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  28. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  29. Zong L, et al. 2021. NPJ Aging Mech Dis. 7:25. PubMed
  30. Huang A, et al. 2014. Exp Cell Res. 15:326. PubMed
  31. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  32. Damal Villivalam S, et al. 2020. Nat Commun. 4313:11. PubMed
  33. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  34. Zhao X, et al. 2022. Cell Biosci. 12:3. PubMed
  35. Rogawski DS, et al. 2021. Nat Commun. 12:2792. PubMed
  36. Suah AN, et al. 2021. J Clin Invest. 131:. PubMed
  37. Sitnik S, et al. 2020. Mol Ther Oncolytics. 17:190. PubMed
  38. Ummarino S, et al. 2021. Cells. 10:. PubMed
  39. Yang Y, et al. 2021. Nat Commun. 12:525. PubMed
  40. Ni P, et al. 2014. J Immunol . 193:1778. PubMed
  41. Rothweiler S, et al. 2019. Purinergic Signal. 0.885416667. PubMed
  42. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  43. Endo J, et al. 2014. J Exp Med. 211:1673. PubMed
  44. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  45. Fang EF, et al. 2019. Nat Neurosci. 22:401. PubMed
  46. Taherzadeh Z, et al. 2010. Am J Physiol Heart Circ Physiol. 298:H1273. PubMed
  47. Ruf B, et al. 2021. Cancer Immunol Res. 9:1024. PubMed
  48. Feng T, et al. 2022. Nat Commun. 13:5208. PubMed
  49. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  50. Khiew SH, et al. 2020. J Clin Invest. 130:3453. PubMed
  51. JI B, et al. 2016. Cell Death Differ. 23:759-75. PubMed
  52. Saravia J, et al. 2015. PLoS Pathog. 11: e1005217. PubMed
  53. Raines A, et al. 2013. Development. 140:2942. PubMed
  54. Michael BD, et al. 2020. Cell Reports. 32(11):108150. PubMed
  55. Leonard JD et al. 2017. Immunity. 47(1):107-117 . PubMed
  56. Matsumura T et al. 2019. Cell Rep. 27(2):561-571 . PubMed
  57. Adams NM et al. 2018. Immunity. 48(6):1172-1182 . PubMed
  58. Fatkhullina AR et al. 2018. Immunity. 49(5):943-957 . PubMed
  59. Krishnamoorthy N, et al. 2015. J Immunol. 194:863. PubMed
  60. Krishnamurthy B, et al. 2015. Diabetes. 64: 3229-3238. PubMed
  61. Wiedemann GM, et al. 2020. Cell Rep. 33:108498. PubMed
  62. Li N, et al. 2021. eLife. 10:00. PubMed
  63. Si Y, et al. 2018. J Control Release. 282:120. PubMed
  64. Diaz–Salazar C, et al. 2020. Cell Rep. 32:108186. PubMed
  65. Belgiovine C, et al. 2021. Eur J Immunol. 51:2677. PubMed
  66. Ren K, et al. 2022. Brain Behav. 12:e2456. PubMed
  67. Bauer T, et al. 2021. Life (Basel). 11:. PubMed
  68. Wu Y, et al. 2021. PLoS Negl Trop Dis. 15:e0010050. PubMed
  69. Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed
  70. Calcinotto A, et al. 2018. Nat Commun. 9:4832. PubMed
  71. Malik A et al. 2018. Immunity. 49(3):515-530 . PubMed
  72. Grioni M, et al. 2021. Blood Adv. 5:2817. PubMed
  73. Qian J, et al. 2021. Int J Mol Sci. 22:. PubMed
  74. Qin Q, et al. 2021. Cell Reports. 35(8):109161. PubMed
  75. Bijalwan M, et al. 2019. Sci Rep. 9:3444. PubMed
  76. Cheng Y, et al. 2019. Cell Rep. 28:1703. PubMed
  77. Sun P, et al. 2022. Nat Commun. 13:6562. PubMed
  78. Zhang X, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  79. Daneshmandi S, et al. 2021. Elife. 10:. PubMed
  80. Park HB, et al. 2020. Nat Microbiol. 1319:5. PubMed
  81. Liu X, et al. 2020. Cell Host Microbe. 28(5):683-698.e6. PubMed
  82. Jonas B, et al. 2016. PLoS One. 11: 0159189. PubMed
  83. Fournier M, Bijl C 2015. Stem Cells Dev. 24: 2413-2422. PubMed
  84. Yahagi A, et al. 2019. RMD Open. 5:e000853. PubMed
  85. K?lin S et al. 2017. Cell metabolism. 26(3):475-492 . PubMed
  86. Souza SP, et al. 2021. PLoS Pathog. 17:e1010081. PubMed
  87. Gamrekelashvili J, et al. 2021. Bio Protoc. 11:e4007. PubMed
  88. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  89. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  90. Kar S, Colino J, Snapper C 2016. J Immunol. 196: 4204 - 4213. PubMed
  91. Chandra J, et al. 2016. Immunol Cell Biol. 10.1038/icb.2016.83. PubMed
  92. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  93. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  94. Tomlinson JE, et al. 2020. J Neurosci Methods. 331:108483. PubMed
  95. Barman S, et al. 2016. Int Immunol. 28: 533 - 545. PubMed
  96. Yeung F, et al. 2020. Cell Host & Microbe. 27(5):809-822. PubMed
  97. Vacca F, et al. 2020. eLife. 9:e54017.. PubMed
  98. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  99. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  100. Agrawal M, et al. 2022. Blood. 140:1094. PubMed
  101. O'Leary CE, et al. 2021. Curr Protoc. 1:e77. PubMed
  102. Nacer A, et al. 2014. PLoS Pathog. 10:1004528. PubMed
  103. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  104. Resch TK, et al. 2018. Sci Rep. 0.722916667. PubMed
  105. Watson N, et al. 2015. J Immunol. 194:2796. PubMed
  106. Grayczyk JP et al. 2017. Cell host & microbe. 22(5):678-687 . PubMed
  107. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  108. Hill RZ, et al. 2018. Elife. 7:e33285. PubMed
  109. Chao JL, et al. 2021. Cell Rep Med. 2:100399. PubMed
  110. Tang S, et al. 2022. Virol J. 19:32. PubMed
  111. Fitzpatrick Z, et al. 2020. Nature. 587:472. PubMed
  112. Deliyannis G, et al. 2021. JCI Insight. 6:. PubMed
  113. Montes de Oca M, et al. 2016. PLoS Pathog. 12: 1005398. PubMed
  114. Sheppard S, et al. 2021. Cell Reports. 35(9):109210. PubMed
  115. Hong S et al. 2018. Immunity. 49(4):695-708 . PubMed
  116. Jaitin DA et al. 2016. Cell. 167(7):1883-1896 . PubMed
  117. Nguyen GT, et al. 2020. eLife. 9:e56656.. PubMed
  118. Smith LK, et al. 2021. Elife. 10:. PubMed
  119. Endo-Umeda K, et al. 2021. Sci Rep. 11:22595. PubMed
  120. Kurashima Y, et al. 2021. Nat Commun. 12:1067. PubMed
  121. Vaas M, et al. 2016. J Cereb Blood Flow Metab. 10.1177/0271678X16676825. PubMed
  122. Martins R, et al. 2016. Nat Immunol. 17:1361-1372. PubMed
  123. Chen S, et al. 2015. Cancer Res . 7: 519-531. PubMed
  124. Kratochvill F, et al. 2015. Cancer Res. 75: 3054-3064. PubMed
  125. Roberts L, et al. 2014. Infect Immun . 82:2504. PubMed
  126. Tomlinson JE, et al. 2018. J Neuroinflammation. 0.753472222. PubMed
  127. Geary CD et al. 2018. Cell reports. 24(8):1949-1957 . PubMed
  128. Mazumder S, et al. 2021. Heliyon. 7:e08124. PubMed
  129. Strait AA, et al. 2021. Commun Biol. 4:1005. PubMed
  130. Stienstra R, et al. 2014. Diabetes. 63:4143. PubMed
  131. Serr I, et al. 2016. Nat Commun. 7:10991. PubMed
  132. Parker K, Horn L, Ostrand-Rosenberg S 2016. J Leukoc Biol. 100: 463 - 470.. PubMed
  133. Young JS, et al. 2018. Front Immunol. 9:1385. PubMed
  134. Park SM et al. 2018. Cell stem cell. 24(1):153-165 . PubMed
  135. Zhong J, et al. 2021. Commun Biol. 4:865. PubMed
  136. Zhang L, et al. 2021. Mol Ther. 29:744. PubMed
  137. Denk F, et al. 2016. Cell Rep. 15: 1771-1781. PubMed
  138. Smith K, et al. 2012. Infect Immun . 80:3481. PubMed
  139. Brenner E, et al. 2020. Nat Commun. 11:1335. PubMed
  140. Kubli SP, et al. 2019. Nat Commun. 10:2678. PubMed
  141. Yá?ez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  142. Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed
  143. Buschor S, et al. 2017. PLoS Pathogens. 13(6):e1006476. PubMed
RRID
AB_755985 (BioLegend Cat. No. 101223) AB_755986 (BioLegend Cat. No. 101224)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

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