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APC/Fire™ 750 anti-mouse/human CD11b Antibod
产品名称：
APC/Fire™ 750 anti-mouse/human CD11b Antibod
产品类别：
抗体
产品编号：
101261
产品应用：
101261
[价格]
规格 价格 库存
25µg ￥ 1344 1

产品详情

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Fire? 750 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

* APC/Fire? 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.

Application Notes

Clone M1/70 has been verified for?immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) (Cat. No. 101248).

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  36. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  2. Hagan N, et al. 2020. Cell Death Dis. 1.086111111. PubMed
  3. Mathur S, et al. 2021. JCI Insight. 6:. PubMed
  4. Sharma D, et al. 2022. Commun Biol. 5:479. PubMed
  5. Li Y, et al. 2021. Brain Behav Immun. 91:267. PubMed
  6. Barman PK, et al. 2019. J Immunol. 202:2720. PubMed
  7. Stotesbury C, et al. 2020. J Immunol. 204:1582. PubMed
  8. Barsoumian HB, et al. 2020. J Immunother Cancer. 8:00. PubMed
  9. Cohen SB et al. 2018. Cell host & microbe. 24(3):439-446 . PubMed
  10. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  11. Matsumoto K, et al. 2017. PLoS One. 12(6):e0175406. PubMed
  12. Ritzel RM, et al. 2021. Glia. 69:746. PubMed
  13. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  14. Cartwright ANR, et al. 2021. Cancer Immunol Res. 9:470. PubMed
  15. Lam KC, et al. 2021. Cell. 184:5338. PubMed
  16. Alhudaithi SS, et al. 2020. Mol Pharm. 17:4691. PubMed
  17. Sugita Y, et al. 2021. Oncol Rep. 45:. PubMed
  18. Li Y, et al. 2022. Theranostics. 12:5364. PubMed
  19. Tao Z, et al. 2022. Cells. 11:. PubMed
  20. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  21. Barsoumian HB, et al. 2022. Cancers (Basel). 14:. PubMed
  22. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  23. Kurashima Y, et al. 2021. Nat Commun. 12:1067. PubMed
  24. Li Y, et al. 2020. Theranostics. 10:11376. PubMed
  25. Kumar D, et al. 2018. Cancer Prev Res (Phila). 0.895138889. PubMed
  26. Goc J, et al. 2021. Cell. :. PubMed
  27. Schuran FA, et al. 2020. Cell Mol Gastroenterol Hepatol. . PubMed
  28. Caetano MS, et al. 2019. Clin Cancer Res. 25:7576. PubMed
  29. Safaee MM, et al. 2022. Sci Rep. 12:1464. PubMed
  30. C Khouili S, et al. 2020. Cell Rep. 33:108468. PubMed
RRID
AB_2572121 (BioLegend Cat. No. 101261) AB_2572122 (BioLegend Cat. No. 101262)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

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