Purified anti-mouse CD301a (MGL1) Antibody
- 产品名称：
- Purified anti-mouse CD301a (MGL1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 145602
- 产品应用：
- 145602
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Purified and recombinant mouse MGL1
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IHC-F, IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
LOM-8.7 specifically recognizes mouse CD301a. Additional reported applications (for relevant formats) include: immunohistochemical staining of frozen tissue sections1-3, immunoprecipitation4, and blocking of MGL1 binding to its ligand4.
- Application References
(PubMed link indicates BioLegend citation) -
- Denda-Nagai K, et al. 2010. J. Biol. Chem. 285:19193. (IHC)
- Sato K, et al. 2005. Blood 106:207. (IHC)
- Tsuiji M, et al. 2002. J. Biol. Chem. 277:28892. (IHC)
- Kimura T, et al. 1995. J. Biol. Chem. 270:16056. (IP, Block)
- Product Citations
-
- Ydens E, et al. 2020. Nat Neurosci. 23:676. PubMed
- RRID
- AB_2561958 (BioLegend Cat. No. 145602)
- Structure
- 42 kD type II transmembrane glycoprotein, containing a cytoplasmic domain, a transmembrane domain, a neck domain, and a carbohydrate recognition domain (CRD) within each molecule
- Distribution
-
Immature myeloid dendritic cells, a subset of macrophages
- Function
- Cell adhesion, cell-cell signaling, glycoprotein turnover, inflammation, tissue remodeling
- Interaction
- Carbohydrate determinants, GP envelope glycoprotein on Marburg and Ebola viruses
- Ligand/Receptor
- Sialoadhesin, apoptotic cells, and commensal bacteria such as Streptococcus sp
- Cell Type
- Dendritic cells, Macrophages
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Denda-Nagai K, et al. 2010. J. Biol. Chem. 285:19193.
2. Westcott D, et al. 2009. J. Exp. Med. 206:3143.
3. Singh SK, et al. 2008. Mol. Immunol. 46:1240.
4. Sakakura M, et al. 2008. J. Biol. Chem. 283:33665.
5. Tsuiji M, et al. 2002. J. Biol. Chem. 277:28892.
- Gene ID
- 17312 View all products for this Gene ID
- UniProt
- View information about CD301a on UniProt.org
