APC anti-human CD114 (G-CSFR) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1788	1

Product Details

Verified Reactivity

Human

Reported Reactivity

Cynomolgus

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

CHO cells transfected with hG-CSFR

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser

Red Laser (633 nm)

Application References (PubMed link indicates BioLegend citation)

Layton JE, et al. 1997. Growth Factors. 14:117
Layton JE, et al. 1999. J. Biol. Chem. 274:17445
Layton JE, et al. 2001. J. Biol. Chem. 276:36779
Gupta K, et al. 2014. Blood. 123:2550. PubMed

Product Citations

Gupta K, et al. 2014. Blood. 123:2550. PubMed
Zhang H, et al. 2017. Leukemia. 10.1128/mBio.00226-17. PubMed
Alhaj Hussen K, et al. 2017. Immunity. 47:680. PubMed
Br?uer-Hartmann D, et al. 2015. Cancer Res . 75: 3411-3424. PubMed

RRID

AB_2229794 (BioLegend Cat. No. 346107) AB_2083866 (BioLegend Cat. No. 346108)

Antigen Details

Structure: Single chain type I transmembrane molecule of 130 kD. The extracellular domain consists of an immunoglobulin-like domain, a cytokine receptor homologue domain, and three fibronectin type III repeats. To function as a receptor, this molecules form a homod
Distribution: Granulocytes (in all stages of differentiation), monocytes, platelets, endothelial cells, placenta and trophoblasts.
Function: Stimulates survival, proliferation, and maturation of neutrophil precursors. In mature neutrophils increases survival, superoxide anion generation, arachidonic acid release, production of myeloperoxidase and leukocyte alkaline phosphatase (LAP).
Interaction: Syk, Lyn, Jak1, Jak2, Tyk2, SOCS3, SOCS1, STAT5, Shp1.
Ligand/Receptor: CSF3(G-CSF)
Bioactivity: Stimulate the proliferation and differentiation of neutrophils precursors and the activation of mature neutrophils.
Cell Type: Endothelial cells, Granulocytes, Monocytes, Neutrophils, Platelets
Biology Area: Immunology
Molecular Family: Adhesion Molecules, CD Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. Starnes LM, et al. 2009. Blood 114:1753
2. Skokowa J, et al. 2009. Nat Med. 15:151
3. Ai J, et al. 2008. PLoS One. 3:e3422
4. Germeshausen M, et al. 2008. Curr Opin Hematol. 15:332
5. Marino VJ, Roguin LP, et al. 2008. J Cell Biochem. 103:1512
6. Irandoust MI, et al. 2007. EMBO J. 2:1782
Gene ID: 1441 View all products for this Gene ID
UniProt: View information about CD114 on UniProt.org

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