Purified anti-human CD1c Antibody
- 产品名称：
- Purified anti-human CD1c Antibody
- 产品类别：
- 抗体
- 产品编号：
- 331501
- 产品应用：
- 331501
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IHC-F, IHC-P - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue4, 5,?formalin-fixed paraffin-embedded immunohistochemical staining6, and spatial biology (IBEX)7,8.
- Application References
(PubMed link indicates BioLegend citation) -
- del C Salamone M, et al. 2001. J Leukoc Biol. 70:567.
- de Fraissinette A, et al. 1988. Exp Hematol. 16:764.
- Li D, et al. 2012. J Exp Med. 209:109. PubMed
- Xu C, et al. 2010. Am J Hematol. 85:539 (IHC-F)
- Gerlini G, et al. 2001. J Invest Dermatol. 117:576 (IHC-F)
- Poposki J, et al. 2016. Clin Exp Allergy 45:384 (IHC-P) PubMed
- Radtke AJ,?et al. 2020.?Proc Natl Acad Sci USA. 117:33455-33465. (SB)?PubMed
- Radtke AJ,?et al. 2022.?Nat Protoc. 17:378-401. (SB)?PubMed
- Product Citations
-
- Dhariwala MO, et al. 2020. Cell Rep Med. 1:100132. PubMed
- Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
- Melo-Gonzalez F, et al. 2018. J Biol Chem. 293:8543. PubMed
- Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed
- Taft J, et al. 2021. Cell. 184(17):4447-4463.e20. PubMed
- Alcántara-Hernández M, et al. 2021. Nat Protoc. 16:4855. PubMed
- Gide TN, et al. 2019. Cancer Cell. 35:238. PubMed
- Liu X, et al. 2022. STAR Protoc. 3:101310. PubMed
- Li D, et al. 2012. J Exp Med. 209:109. PubMed
- Li Y, et al. 2019. Front Immunol. 0.460416667. PubMed
- Guo T, et al. 2018. J Immunol. 200:500. PubMed
- Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
- Rybakowska P, et al. 2022. STAR Protoc. 3:101697. PubMed
- Borges TJ, et al. 2018. Nat Commun. 9:3482. PubMed
- Farhadian SF, et al. 2022. JCI Insight. 7:. PubMed
- Lee YS, et al. 2021. J Immunother Cancer. 9:. PubMed
- Jordan S, et al. 2020. Cell. 178(5):1102-1114.e17.. PubMed
- Gherardin NA, et al. 2021. Cancer Immunol Res. 9:612. PubMed
- Cillo AR, et al. 2021. Cell Rep Med. 2:100476. PubMed
- Kuzmina NA, et al. 2018. Cell Rep. 24:1802. PubMed
- Kennedy-Darling J, et al. 2021. Eur J Immunol. 51:1262. PubMed
- Stensland ZC, et al. 2022. iScience. 25:103626. PubMed
- Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
- Sander J et al. 2017. Immunity. 47(6):1051-1066 . PubMed
- Cytlak U, et al. 2020. Immunity. 53(2):353-370. PubMed
- Waugh KA, et al. 2020. Cell Reports. 29(7):1893-1908.e4.. PubMed
- Leylek R, et al. 2020. Cell Rep. 32:108180. PubMed
- Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
- RRID
- AB_1088996 (BioLegend Cat. No. 331501) AB_1088995 (BioLegend Cat. No. 331502)
- Structure
- 43 kD, Ig superfamily, MHC I-like molecule, associates with β2-microglobulin
- Distribution
-
B cell subset, cortical thymocytes, dendritic cells, and Langerhans cells
- Function
- Presents lipid antigen to CD1c-restricted T cells
- Ligand/Receptor
- CD1c-restricted TCR
- Cell Type
- B cells, Dendritic cells, Langerhans cells, Thymocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Fainboim LM and del C. Salamone. 2002. J. Biol. Reg. Homeos. Ag. 16:125.
2. M. del Salamone C, et al. 2001. J. Leukocyte Biol. 70:567.
3. Zola H, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. P42.
- Gene ID
- 911 View all products for this Gene ID
- UniProt
- View information about CD1c on UniProt.org
