Purified anti-human CD192 (CCR2) Antibody
- 产品名称：
- Purified anti-human CD192 (CCR2) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 357201
- 产品应用：
- 357201
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- CCR2 DNA immunogen
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Epitope of clone K036C2 has been mapped to amino acids 11-29 and 21-39 of human CCR2.
- Application References
(PubMed link indicates BioLegend citation) -
- Tanaka T,?et al. 2022. Monoclon Antib Immunodiagn Immunother. 41(5):285-289 (Epitope)
- Product Citations
-
- Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
- Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed
- Song S, et al. 2021. Commun Biol. 4:1338. PubMed
- Zhao BN, et al. 2019. J Immunol. 203:3157. PubMed
- Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed
- Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
- Chevrier S, et al. 2018. Cell Syst. 0.675. PubMed
- RRID
- AB_2561850 (BioLegend Cat. No. 357201) AB_2561851 (BioLegend Cat. No. 357202)
- Structure
- Chemokine receptor, GPCR, seven transmembrane receptor
- Distribution
-
Monocytes, macrophages, immature dendritic cells, memory T cells
- Function
- Induces monocyte adhesion to endothelial cells and chemotaxis
- Ligand/Receptor
- CCL2 (MCP-1), CCL7 (MCP-3), CCL8 (MCP-2), CCL13 (MCP-4), CCL16 (HCC4)
- Cell Type
- Dendritic cells, Macrophages, Monocytes, T cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
1. Wong LM, et al. 1997. J. Biol. Chem. 272:1038.
2. Papadopoulou C, et al. 2008. Cytokine 43:181.
3. Barlic J, et al. 2007. J. Leukoc. Biol. 82:226.
4. Gu L, et al. 1998. Mol. Cell 2:275.
5. Volpe S, et al. 2012. PLoS One. 7:e37208.
- Gene ID
- 729230 View all products for this Gene ID
- UniProt
- View information about CD192 on UniProt.org
