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PE anti-human IL-13 Antibody
产品名称：
PE anti-human IL-13 Antibody
产品类别：
抗体
产品编号：
501903
产品应用：
501903
[价格]
规格 价格 库存
25tests ￥ 1320 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
COS-expressed, recombinant human IL-13
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

ELISA or ELISPOT Capture1,2: The Ultra-LEAF? Purified JES10-5A2 antibody is useful as the capture antibody in a sandwich ELISA or ELISPOT assay, when used in conjunction with the biotinylated Poly5020 antibody (Cat. No. 502001) as the detecting antibody. The Ultra-LEAF? Purified antibody is suggested for ELISPOT capture.

Application References

(PubMed link indicates BioLegend citation)
  1. McKenzie, A., et al. 1994. Curr. Prot. Immunol.. John Wiley & Sons. New York. Section 6.18.
  2. Abrams, J. 1995. Curr. Prot. Immunol.. John Wiley and Sons, New York. Unit 6.20.
  3. Schaerli, P., et al. 2000. J. Exp. Med. 192:1553.
  4. Andersson, J., et al. 1994. Immunology 83:16.
  5. Skansen-Saphir, U., et al. 1994. Eur. J. Immunol. 24:916.
  6. Andersson, U., et al. 1999. Detection and quantification of gene expression. New York:Springer-Verlag.
  7. Gelfand, E. W., et al. 2006. J. Aller. and Clinic. Immunol. 117:577.
  8. Knorr, C., et al. 1999. Am. J. Pathol. 155:2019.
Product Citations
  1. Ols S, et al. 2020. Cell Reports. 30(12):3964-3971. PubMed
  2. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  3. Kongsbak M, et al. 2014. PLoS One. 9:96695. PubMed
  4. Golebski K, et al. 2019. Nat Commun. 10:2162. PubMed
  5. Boer M, et al. 2015. Clin Vaccine Immunol. 22: 778 - 788. PubMed
  6. Amelio P, et al. 2017. PLoS Negl Trop Dis. 10.1371/journal.pntd.0005817. PubMed
  7. Rodda LB, et al. 2020. Cell. 184(1):169-183.e17. PubMed
  8. Shen C, et al. 2021. Front Immunol. 12:680055. PubMed
  9. Yan J, et al. 2020. Cell Rep. 107820:31. PubMed
  10. Golebski K, et al. 2021. Immunity. 54(2):291-307.e7. PubMed
  11. Guimar?es F, et al. 2017. J Pediatr (Rio J). 10.1016/j.jped.2017.08.005. PubMed
  12. Katsuyama E, et al. 2020. Cell Reports. 30(1):112-123.e4.. PubMed
  13. Hirota K et al. 2018. Immunity. 48(6):1220-1232 . PubMed
RRID
AB_315198 (BioLegend Cat. No. 501903)

Antigen Details

Structure
Cytokine; 17 kD (Mammalian)
Bioactivity
Suppression of macrophage cytotoxic activity; upregulation of IL-1RA expression; suppression of IL-1, IL-6, IL-8, IL-10, IL-12, chemokines MCP, MIP-1; differentiation of B cells, monocytes
Cell Sources
Activated T cells, mast cells, NK cells
Cell Targets
B cells, monocytes, macrophages, basophils
Receptors
Moderate affinity IL-13Rα1; high affinity heterodimer IL-13Rα1/IL-4Rα also binds IL-4; both receptor complexes have γ-subunit in common with IL-2R, IL-4R, IL-7R, IL-15R ; high affinity IL-13Rα2 incapable of signaling
Cell Type
Tregs
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Fitzgerald, K., et al. Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego.
2. Hilton, D., et al. 1996. P. Natl. Acad. Sci. USA 93:497.
3. Obiri, N., et al. 1995. J. Biol. Chem. 270:8797.
4. Ochensberger, B., et al. 1996. Blood 88:3028.

Regulation
IL-13Rα2 possible antagonist
Gene ID
3596 View all products for this Gene ID
UniProt
View information about IL-13 on UniProt.org

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