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首页 > 抗体蛋白 > 抗体
PE anti-human CD86 Antibody
产品名称：
PE anti-human CD86 Antibody
产品类别：
抗体
产品编号：
305405
产品应用：
305405
[价格]
规格 价格 库存
25tests ￥ 1320 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Capuchin Monkey, Common Marmoset, Cotton-topped Tamarin, Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
?g size: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
test sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
?g sizes: 0.2 mg/mL
test sizes: lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining using the ?g size, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application. For flow cytometric staining using the test sizes, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections6, Western blotting3, and blocking of T cell activation2,4,5. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 305449 & 305450).

Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dieu M. 1998. J. Exp. Med. 188:373. (Block)
  3. Esser M, et al. 2001. J. Virol. 75:6173. (WB)
  4. Jeannin P, et al. 1999. J. Immunol. 162:2044. (Block)
  5. Kapsogeorgou EK, et al. 2001. J. Immunol. 166:3107. (Block)
  6. Geissmann F, et al. 2001. Blood 97:1241. (IHC)
Product Citations
  1. Wang X, et al. 2019. Cell Res. 29:787. PubMed
  2. Rampal R, Awasthi A, Ahuja V 2016. Sci Rep. 6:30277. PubMed
  3. Macal M, et al. 2016. J Immunol. 196: 1900 - 1909. PubMed
  4. Casasola-LaMacchia A, et al. 2021. Sci Rep. 11:1028. PubMed
  5. Schimek V, et al. 2022. Cell Death Dis. 13:113. PubMed
  6. Li H, et al. 2016. J Immunol. 196: 4064 - 4074. PubMed
  7. Gu C, et al. 2019. J Immunol. 203:389. PubMed
  8. Sugawara E, et al. 2020. Autophagy. 1.323611111. PubMed
  9. Bosco M, et al. 2011. Blood. 117:2625. PubMed
  10. Philippeos C, et al. 2018. J Invest Dermatol. 138:811. PubMed
  11. Kan S, et al. 2020. Int J Oncol. 57:1047. PubMed
  12. Laing AG, et al. 2020. Nat Med. 26:1623. PubMed
  13. Du X, et al. 2018. Cell Res. 28:416. PubMed
  14. Wang X, et al. 2021. Front Physiol. 12:644903. PubMed
  15. Haruna M, et al. 2020. Biol Pharm Bull. 43:399. PubMed
  16. Lin JR et al. 2018. eLife. 7 pii: e31657. PubMed
  17. Jankeel A, et al. 2020. J Virol. :94. PubMed
  18. Hofbauer D, et al. 2021. Immunity. 54(8):1772-1787.e9. PubMed
  19. Oulès B, et al. 2020. Nat Commun. 3.977083333. PubMed
  20. Bryson BD, et al. 2019. Nat Commun. 10:2329. PubMed
  21. Stoeker L, et al. 2011. Clin Vaccine Immunol. 2.023611111. PubMed
  22. Mendoza-Cabrera MI, et al. 2019. Innate Immun. :1753425919864658. PubMed
  23. Yamada KJ, et al. 2020. PLoS Pathog. 16:e1008354. PubMed
  24. Blaszczak AM, et al. 2019. J Diabetes Res. 2019:8124563. PubMed
  25. Su S et al. 2018. Cell. 175(2):442-457 . PubMed
  26. Li X, et al. 2021. Cell Death Dis. 12:314. PubMed
  27. Barman S, et al. 2016. Int Immunol. 28: 533 - 545. PubMed
  28. Planès R, et al. 2014. J Virol. 88:6672. PubMed
  29. Donini M, et al. 2011. Prostate. 72:566. PubMed
  30. Fiola S, et al. 2010. J Immunol. 185:3620. PubMed
  31. Herati RS, et al. 2022. Nat Immunol. 23:1183. PubMed
  32. Que Y, et al. 2021. Front Immunol. 12:653030. PubMed
  33. Seeger P, et al. 2014. J Immunol. 192:1241. PubMed
  34. Luvanda MK, et al. 2021. J Fungi (Basel). 7:. PubMed
  35. Wang X, et al. 2012. J Immunol. 189:3092. PubMed
  36. Finotti G, et al. 2016. J Leukoc Biol. 99: 107 - 119. PubMed
  37. Koh WH, et al. 2020. STAR Protoc. 1:100203. PubMed
  38. Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
  39. Welch JL, et al. 2020. FEBS Lett. 594:695. PubMed
  40. Wee Y, et al. 2016. Exp Biol Med. 241: 1217 - 1228. PubMed
RRID
AB_314525 (BioLegend Cat. No. 305405) AB_2564164 (BioLegend Cat. No. 305438) AB_314526 (BioLegend Cat. No. 305406)

Antigen Details

Structure
Ig superfamily, single-chain transmembrane glycoprotein, 80 kD
Distribution

Monocytes/macrophages, activated B cells and T cells, dendritic cells

Function
T cell costimulation
Ligand/Receptor
CD28, CD152
Cell Type
B cells, Dendritic cells, Macrophages, Monocytes, T cells, Tregs
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Hathcock K, et al. 1996. Adv. Immunol. 62:131.
2. June C, et al. 1994. Immunol. Today 15:321.

Gene ID
942 View all products for this Gene ID
UniProt
View information about CD86 on UniProt.org

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