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APC anti-human CD86 Antibody
产品名称：
APC anti-human CD86 Antibody
产品类别：
抗体
产品编号：
305411
产品应用：
305411
[价格]
规格 价格 库存
25tests ￥ 1788 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Capuchin Monkey, Common Marmoset, Cotton-topped Tamarin, Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections6, Western blotting3, and blocking of T cell activation2,4,5. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 305449 & 305450).

Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dieu M. 1998. J. Exp. Med. 188:373. (Block)
  3. Esser M, et al. 2001. J. Virol. 75:6173. (WB)
  4. Jeannin P, et al. 1999. J. Immunol. 162:2044. (Block)
  5. Kapsogeorgou EK, et al. 2001. J. Immunol. 166:3107. (Block)
  6. Geissmann F, et al. 2001. Blood 97:1241. (IHC)
Product Citations
  1. Ackermann M, et al. 2018. Nat Commun. 9:5088. PubMed
  2. Chometon TQ, et al. 2020. PLoS One. 15:e0231132. PubMed
  3. Vereertbrugghen A, et al. 2021. Front Oncol. 11:598319. PubMed
  4. Meng Y,et al. 2017. Cell Death Dis. . 10.1038/cddis.2017.505. PubMed
  5. Herath S, et al. 2014. PLoS One. 9:88327. PubMed
  6. Kotsiou E, et al. 2016. Blood. 128: 72 - 81. PubMed
  7. Ong SM, et al. 2019. Front Immunol. 10:1761. PubMed
  8. Xu G, et al. 2022. Cell Death Dis. 13:888. PubMed
  9. Hu X, et al. 2016. PLoS One. 11: 0152368. PubMed
  10. Castellaro AM, et al. 2019. Cancers (Basel). 11:. PubMed
  11. Cassetta L et al. 2019. Cancer Cell. 35(4):588-602 . PubMed
  12. Kim SE, et al. 2019. PLoS One. 14:e0223590. PubMed
  13. Muto S, et al. 2021. Oncol Lett. 21:203. PubMed
  14. Hazeldine J, et al. 2017. PLoS Med. 10.1371/journal.pmed.1002338. PubMed
  15. Amo L, et al. 2022. Front Immunol. 13:835527. PubMed
  16. Perera MR, et al. 2022. Int J Mol Sci. 23:. PubMed
  17. Nowak A, et al. 2015. Ann Oncol. 26: 2483 - 2490. PubMed
  18. Csomós K, et al. 2022. Nat Immunol. 23:1256. PubMed
  19. Celis‐Gutierrez J et al. 2019. Cell Rep. 27(11):3315-3330 . PubMed
  20. Longbrake EE, et al. 2018. Mult Scler. 24:728. PubMed
  21. Zhu F, et al. 2022. Front Immunol. 13:879575. PubMed
  22. Nastasi C, et al. 2015. Sci Rep. . PubMed
  23. Papalexi E, et al. 2021. Nat Genet. 53:322. PubMed
  24. Siedlik J, et al. 2017. J Immunol Methods. 10.4049/jimmunol.1700003. PubMed
  25. Pinto SM, et al. 2021. Front Immunol. 12:679458. PubMed
RRID
AB_493232 (BioLegend Cat. No. 305411) AB_493231 (BioLegend Cat. No. 305412)

Antigen Details

Structure
Ig superfamily, single-chain transmembrane glycoprotein, 80 kD
Distribution

Monocytes/macrophages, activated B cells and T cells, dendritic cells

Function
T cell costimulation
Ligand/Receptor
CD28, CD152
Cell Type
B cells, Dendritic cells, Macrophages, Monocytes, T cells, Tregs
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Hathcock K, et al. 1996. Adv. Immunol. 62:131.
2. June C, et al. 1994. Immunol. Today 15:321.

Gene ID
942 View all products for this Gene ID
UniProt
View information about CD86 on UniProt.org

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