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Purified anti-human CD11b Antibody
产品名称：
Purified anti-human CD11b Antibody
产品类别：
抗体
产品编号：
301302
产品应用：
301302
[价格]
规格 价格 库存
100µg ￥ 600 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Chimpanzee, Common Marmoset, Pig
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF? - Verified
ICC, IHC?- Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per 106 cells in 100 ?L?volume or 100 ?L?of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The ICRF44 antibody inhibits heterotypic adhesion of granulocytes in response to fMLP. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections, immunofluorescence microscopy5, stimulation of monocytes3, blocking of heterotypic PMN aggregation8, and blocking of granulocyte activation12. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue.

The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 301361 & 301362).

Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York.
  2. Barclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego.
  3. Rezzonico R, et al. 2001. Blood 97:2932. (Stim)
  4. Marsik C, et al. 2003. Shock 20:493. (FC)
  5. David A, et al. 2003. J. Leukoc. Biol. 74:551. (IF)
  6. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  7. Thurlow LR, et al. 2010. Infect. Immun. 128:1128. (FC) PubMed
  8. Jadhav S, et al. 2001. J. Immunol. 167:5986. (Block)
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Sestak K, et al. 2007. Vet. Immunol. Immunopathol. 119:21. (FC)
  11. Wen T, et al. 2014. J Immunol. 192:5481. (FC) PubMed
  12. Sprong T, et al. 2003. Blood 102:3702. (Block)
  13. Cash JL, et al. 2013. EMBO Rep. 14:999. (FC) PubMed
  14. Larsson K, et al. 2015. PNAS. PubMed
Product Citations
  1. Lu Y, et al. 2017. Cell Mol Immunol. 1.054166667. PubMed
  2. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  3. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  4. Patel AA, et al. 2017. J Exp Med. 214:1913. PubMed
  5. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  6. Heesters BA, et al. 2021. J Exp Med. 218:. PubMed
  7. Noura M, et al. 2020. Sci Rep. 10:20245. PubMed
  8. S?derholm N, et al. 2011. PLoS One. 6:e24353. PubMed
  9. Lukácsi S, et al. 2020. PLoS One. 15:e0232432. PubMed
  10. Farhadian SF, et al. 2022. JCI Insight. 7:. PubMed
  11. Wastyk HC, et al. 2021. Cell. 184(16):4137-4153.e14. PubMed
  12. Agrawal N, et al. 2018. Front Immunol. 2.053472222. PubMed
  13. Han L, et al. 2019. Haematologica. 10.3324/haematol.2018.205534. PubMed
  14. Chen X, et al. 2022. Proc Natl Acad Sci U S A. 119:. PubMed
  15. Wen T, et al. 2014. J Immunol. 192:5481. PubMed
  16. De Maeyer RPH, et al. 2020. Nat Immunol. 21:615. PubMed
  17. Dixit N, et al. 2011. J Immunol. 187:472. PubMed
  18. Zhou H, et al. 2017. Leukemia. 31:2065. PubMed
  19. Nagy-Baló Z, et al. 2021. PLoS One. 16:e0254853. PubMed
  20. Larsson K, et al. 2015. Proc Natl Acad Sci U S A. . PubMed
  21. Ran LJ, et al. 2018. Mol Med Rep. 18:723. PubMed
  22. Percivalle E, et al. 2021. Viruses. 13:. PubMed
  23. Tseng HY, et al. 2018. J Cell Sci. 131. PubMed
  24. Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed
RRID
AB_314154 (BioLegend Cat. No. 301302)

Antigen Details

Structure
Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 165-170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subset of T cells, subset of B cells

Function
Adhesion, phagocytosis, chemotaxis, neutrophil activation
Ligand/Receptor
ICAM-1(CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, factor X
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Stewart M, et al. 1995. Curr?Opin?Cell Biol. 7:690.

Gene ID
3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

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