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首页 > 抗体蛋白 > 抗体
PE anti-human CD11b Antibody
产品名称：
PE anti-human CD11b Antibody
产品类别：
抗体
产品编号：
301305
产品应用：
301305
[价格]
规格 价格 库存
25tests ￥ 528 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Chimpanzee, Common Marmoset, Pig
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

The ICRF44 antibody inhibits heterotypic adhesion of granulocytes in response to fMLP. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections, immunofluorescence microscopy5, stimulation of monocytes3, blocking of heterotypic PMN aggregation8, and blocking of granulocyte activation12. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue.

The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 301361 & 301362).

Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York.
  2. Barclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego.
  3. Rezzonico R, et al. 2001. Blood 97:2932. (Stim)
  4. Marsik C, et al. 2003. Shock 20:493. (FC)
  5. David A, et al. 2003. J. Leukoc. Biol. 74:551. (IF)
  6. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  7. Thurlow LR, et al. 2010. Infect. Immun. 128:1128. (FC) PubMed
  8. Jadhav S, et al. 2001. J. Immunol. 167:5986. (Block)
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Sestak K, et al. 2007. Vet. Immunol. Immunopathol. 119:21. (FC)
  11. Wen T, et al. 2014. J Immunol. 192:5481. (FC) PubMed
  12. Sprong T, et al. 2003. Blood 102:3702. (Block)
  13. Cash JL, et al. 2013. EMBO Rep. 14:999. (FC) PubMed
  14. Larsson K, et al. 2015. PNAS. PubMed
Product Citations
  1. Healy LM, et al. 2020. Glia. 68:811. PubMed
  2. Xin Y, et al. 2021. Stem Cell Res Ther. 49:12. PubMed
  3. Qiu J, et al. 2020. Cell Rep. 33:108465. PubMed
  4. Hoang TN, et al. 2021. Cell. 184:460. PubMed
  5. Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
  6. Miedema A, et al. 2022. Acta Neuropathol Commun. 10:8. PubMed
  7. Li J, et al. 2021. Front Immunol. 12:649285. PubMed
  8. Klichinsky M, et al. 2020. Nat Biotechnol. 38:947. PubMed
  9. Paubelle E, et al. 2020. Cell Reports. 30(3):739-754.e4.. PubMed
  10. Martínez–Rojas PP, et al. 2020. Cells. 0.460416667. PubMed
  11. Kubo M, et al. 2018. Oncol Rep. 39:417. PubMed
  12. Réu P, et al. 2017. Cell Rep. 10.1016/j.celrep.2017.07.004. PubMed
  13. Eriksson E, et al. 2016. Gene Ther. 10.1038/gt.2016.80. PubMed
  14. Kraig E, et al. 2018. Exp Gerontol. 105:53. PubMed
  15. Miao L, et al. 2021. Clin Transl Med. 11:e395. PubMed
  16. Hoang TN, et al. 2020. bioRxiv. . PubMed
  17. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  18. Johnston G, et al. 2020. Gene. 752:144758. PubMed
  19. Kim TH, et al. 2019. FASEB J. 33:3997. PubMed
  20. Qi F, et al. 2022. Oncol Lett. 24:273. PubMed
  21. Ohue Y, et al. 2014. Clin Cancer Res. 20:5052. PubMed
  22. Hasselmann J, et al. 2020. Neuron. 103(6):1016-1033. PubMed
  23. Zhang X, et al. 2019. JCI Insight. 4:2. PubMed
  24. Zhu S, et al. 2022. J Oncol. 2022:8724933. PubMed
  25. Zhang B, et al. 2013. PLoS One. 8:57114. PubMed
  26. Lin H, et al. 2020. Small. 16:e2002194. PubMed
  27. Zhao Y, et al. 2018. Oncol Rep. 40:877. PubMed
  28. Cai S, et al. 2022. Cell Biosci. 12:115. PubMed
  29. Dan W, et al. 2022. Int J Med Sci. 19:525. PubMed
  30. Lee HJ, et al. 2017. Oncotarget. 8:113345. PubMed
  31. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  32. Barman S, et al. 2016. Int Immunol. 28: 533 - 545. PubMed
  33. Ross NT, et al. 2020. Nature Chemical Biology. 16(1):50-59.. PubMed
  34. Smith-Díaz CC, et al. 2021. Front Oncol. 11:709543. PubMed
  35. Britt EC, et al. 2022. Nat Metab. 4:389. PubMed
  36. Rodriguez A, et al. 2021. Cell Stem Cell. 28:33. PubMed
  37. Martinez O, et al. 2013. J Virol. 87:3324. PubMed
  38. Tian L, et al. 2022. Clin Cancer Res. 28:201. PubMed
  39. Dubbelaar ML, et al. 2021. Brain Behav Immun Health. 15:100265. PubMed
  40. Pierini S, et al. 2020. JCI Insight. 5:00. PubMed
  41. Min C, et al. 2017. PLoS One. 10.1371/journal.pone.0169128. PubMed
  42. Medeiros-Furquim T, et al. 2022. Front Immunol. 13:678817. PubMed
  43. Pinto SM, et al. 2021. Front Immunol. 12:679458. PubMed
RRID
AB_314157 (BioLegend Cat. No. 301305) AB_314158 (BioLegend Cat. No. 301306)

Antigen Details

Structure
Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 165-170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subset of T cells, subset of B cells

Function
Adhesion, phagocytosis, chemotaxis, neutrophil activation
Ligand/Receptor
ICAM-1(CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, factor X
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Stewart M, et al. 1995. Curr?Opin?Cell Biol. 7:690.

Gene ID
3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

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