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APC/Cyanine7 anti-human CD11b Antibody
产品名称：
APC/Cyanine7 anti-human CD11b Antibody
产品类别：
抗体
产品编号：
301341
产品应用：
301341
[价格]
规格 价格 库存
25tests ￥ 1848 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Chimpanzee, Common Marmoset, Pig
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

The ICRF44 antibody inhibits heterotypic adhesion of granulocytes in response to fMLP. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections, immunofluorescence microscopy5, stimulation of monocytes3, blocking of heterotypic PMN aggregation8, and blocking of granulocyte activation12. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue.

The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 301361 & 301362).

Additional Product Notes
BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York.
  2. Barclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego.
  3. Rezzonico R, et al. 2001. Blood 97:2932. (Stim)
  4. Marsik C, et al. 2003. Shock 20:493. (FC)
  5. David A, et al. 2003. J. Leukoc. Biol. 74:551. (IF)
  6. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  7. Thurlow LR, et al. 2010. Infect. Immun. 128:1128. (FC) PubMed
  8. Jadhav S, et al. 2001. J. Immunol. 167:5986. (Block)
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Sestak K, et al. 2007. Vet. Immunol. Immunopathol. 119:21. (FC)
  11. Wen T, et al. 2014. J Immunol. 192:5481. (FC) PubMed
  12. Sprong T, et al. 2003. Blood 102:3702. (Block)
  13. Cash JL, et al. 2013. EMBO Rep. 14:999. (FC) PubMed
  14. Larsson K, et al. 2015. PNAS. PubMed
Product Citations
  1. Pan YG, et al. 2022. Methods Mol Biol. 2574:31. PubMed
  2. Hultmark S, et al. 2020. Haematologica. . PubMed
  3. Azizi E et al. 2018. Cell. 174(5):1293-1308 e36. PubMed
  4. Oliva Chávez AS, et al. 2021. Nat Commun. 12:3696. PubMed
  5. Klichinsky M, et al. 2020. Nat Biotechnol. 38:947. PubMed
  6. Pan YG, et al. 2021. Immunity. 54(6):1245-1256.e5. PubMed
  7. Kurkewich J, et al. 2016. PLoS One. 11: 0161468. PubMed
  8. Xia Y, et al. 2019. Gastroenterol Res Pract. 2019:5436961. PubMed
  9. Osorio FG et al. 2018. Cell reports. 25(9):2308-2316 . PubMed
  10. Fujisaka Y, et al. 2018. Oncol Lett. 15:509. PubMed
  11. Hegewisch-Solloa E, et al. 2021. J Immunol. 207:950. PubMed
  12. Zavidij O, et al. 2020. Nat Cancer. 0.384027778. PubMed
  13. Zeng Y et al. 2019. Immunity. 51(5):930-948 . PubMed
  14. Metzemaekers M, et al. 2021. Clin Transl Immunology. 10:e1271. PubMed
  15. Li Y, et al. 2020. Front Cell Dev Biol. 8:604021. PubMed
  16. Abd Hamid M et al. 2019. Cancer Immunol Res. 7(8):1293-1306 . PubMed
RRID
AB_2563371 (BioLegend Cat. No. 301341) AB_2563395 (BioLegend Cat. No. 301342)

Antigen Details

Structure
Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 165-170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subset of T cells, subset of B cells

Function
Adhesion, phagocytosis, chemotaxis, neutrophil activation
Ligand/Receptor
ICAM-1(CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, factor X
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Stewart M, et al. 1995. Curr?Opin?Cell Biol. 7:690.

Gene ID
3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

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