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APC anti-human CD11b Antibody
产品名称：
APC anti-human CD11b Antibody
产品类别：
抗体
产品编号：
301309
产品应用：
301309
[价格]
规格 价格 库存
25tests ￥ 528 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Chimpanzee, Common Marmoset, Pig
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
?g size: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
test sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
?g sizes: 0.2 mg/mL
test sizes: lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining using the ?g size, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application. For flow cytometric staining using the test sizes, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

The ICRF44 antibody inhibits heterotypic adhesion of granulocytes in response to fMLP. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections, immunofluorescence microscopy5, stimulation of monocytes3, blocking of heterotypic PMN aggregation8, and blocking of granulocyte activation12. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue.

The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 301361 & 301362).

Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York.
  2. Barclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego.
  3. Rezzonico R, et al. 2001. Blood 97:2932. (Stim)
  4. Marsik C, et al. 2003. Shock 20:493. (FC)
  5. David A, et al. 2003. J. Leukoc. Biol. 74:551. (IF)
  6. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  7. Thurlow LR, et al. 2010. Infect. Immun. 128:1128. (FC) PubMed
  8. Jadhav S, et al. 2001. J. Immunol. 167:5986. (Block)
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Sestak K, et al. 2007. Vet. Immunol. Immunopathol. 119:21. (FC)
  11. Wen T, et al. 2014. J Immunol. 192:5481. (FC) PubMed
  12. Sprong T, et al. 2003. Blood 102:3702. (Block)
  13. Cash JL, et al. 2013. EMBO Rep. 14:999. (FC) PubMed
  14. Larsson K, et al. 2015. PNAS. PubMed
Product Citations
  1. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  2. Guo X, et al. 2016. Mol Ther Methods Clin Dev. 3:15054. PubMed
  3. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  4. Schimek V, et al. 2022. Cell Death Dis. 13:113. PubMed
  5. Richardson SE, et al. 2021. STAR Protocols. 2(2):100420. PubMed
  6. Schwabenland M, et al. 2021. Acta Neuropathol. 142:923. PubMed
  7. André V, et al. 2012. Blood Cancer J. 2:94. PubMed
  8. Saggu G, et al. 2018. Nat Commun. 9:5058. PubMed
  9. Hemkemeyer SA, et al. 2020. J Biol Chem. 296:100136. PubMed
  10. Hünniger K, et al. 2015. J Immunol. 194:1199. PubMed
  11. Wang E, et al. 2021. Cell Stem Cell. 28(4):718-731.e6. PubMed
  12. Morton JJ, et al. 2018. Mol Carcinog. 57:1651. PubMed
  13. Li Y, et al. 2022. Cell Rep. 38:110284. PubMed
  14. Perelman SS, et al. 2021. Nat Microbiol. 6:731. PubMed
  15. Dan H, et al. 2020. Mol Oncol. 14:795. PubMed
  16. Eriksson E, et al. 2019. J Immunol. 202:787. PubMed
  17. Szentkereszty M, et al. 2020. Pathol Oncol Res. 26:1117. PubMed
  18. Johnston G, et al. 2020. Gene. 752:144758. PubMed
  19. Berger M, et al. 2012. J Biol Chem. 287:19409. PubMed
  20. Yang E, et al. 2021. Exp Mol Med. 53:1902. PubMed
  21. Krampert L, et al. 2021. Front Immunol. 12:712948. PubMed
  22. Velázquez–Avila M, et al. 2019. Leukemia. 33:1337. PubMed
  23. Hazeldine J, et al. 2017. PLoS Med. 10.1371/journal.pmed.1002338. PubMed
  24. Surdziel E, et al. 2017. PLoS One.. 10.1371/journal.pone.0183679. PubMed
  25. Zelter T, et al. 2022. EMBO Rep. 23:e53641. PubMed
  26. Wegner J, et al. 2021. Sci Rep. 11:14983. PubMed
  27. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  28. Hemkemeyer SA, et al. 2020. J Biol Chem. . PubMed
  29. Collado A, et al. 2021. Front Pharmacol. 12:656244. PubMed
  30. Horn LA, et al. 2017. Oncotarget. 8:57964. PubMed
  31. Kiehlmeier S, et al. 2021. Leukemia. Online ahead of prin. PubMed
  32. Konduru NV, et al. 2021. Nanotheranostics. 5:309. PubMed
  33. Luque-Martin R, et al. 2021. J Immunol. 207:555. PubMed
  34. Sun Z, et al. 2013. PLoS One. 8:74672. PubMed
  35. Bigley V, et al. 2015. J Leukoc Biol. 97:627. PubMed
  36. Fu Y, et al. 2021. Cell Reports. 36(2):109344. PubMed
  37. Sade-Feldman M, et al. 2016. Clin Cancer Res. 22(23):5661-5672. PubMed
  38. Halim TYF et al. 2018. Immunity. 48(6):1195-1207 . PubMed
  39. Jardine L, et al. 2019. Nat Commun. 10:1999. PubMed
  40. Qiu X, et al. 2022. Cell. 185:690. PubMed
  41. Julian Buchrieser, William James, Michael D. Moore 2017. Stem Cell Reports. 8(2):334-345. PubMed
  42. Zhai Y, et al. 2018. Autophagy. 1.714583333. PubMed
  43. Thurlow L, et al. 2010. Infect Immun. 78:4936. PubMed
  44. Wu X, et al. 2022. Front Immunol. 13:849493. PubMed
  45. Ren X, et al. 2021. Cell Death Dis. 12:484. PubMed
RRID
AB_314161 (BioLegend Cat. No. 301309) AB_314162 (BioLegend Cat. No. 301310) AB_2564134 (BioLegend Cat. No. 301350)

Antigen Details

Structure
Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 165-170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subset of T cells, subset of B cells

Function
Adhesion, phagocytosis, chemotaxis, neutrophil activation
Ligand/Receptor
ICAM-1(CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, factor X
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Stewart M, et al. 1995. Curr?Opin?Cell Biol. 7:690.

Gene ID
3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

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