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Purified anti-human CD158 (KIR2DL1/S1/S3/S5) Antib
产品名称:
Purified anti-human CD158 (KIR2DL1/S1/S3/S5) Antib
产品类别:
抗体
产品编号:
339502
产品应用:
339502
[价格]
规格 价格 库存
100µg ¥ 1344 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Baboon, Cynomolgus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human NK cell clone LB2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

mAb HP-MA4 reacts with KIR2DL1 (CD158a), KIR2DS1 (CD158h), KIR2DS3, and KIR2DS5 (CD158g).

Additional reported applications include: inhibits NK cell mediated cytotoxicity and immunoprecipitation.

This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).

Application References

(PubMed link indicates BioLegend citation)
  1. De Miguel M and M. Lopez-Botet. 2002. Inmunologia. 21:187
  2. Goodridge JP, et al. 2013. J. Immunol. 191:3553. PubMed
RRID
AB_1501078 (BioLegend Cat. No. 339502)

Antigen Details

Structure
Contains two Ig-like extracellular domains, 58/50 kD
Distribution

Subset of NK cells and a small subset of CD8+ T cells

Function
Inhibits NK cell function, play a role in self-tolerance.
Ligand/Receptor
HLA-C
Cell Type
NK cells, T cells
Biology Area
Immunology, Inhibitory Molecules
Molecular Family
CD Molecules
Antigen References

1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication

Gene ID
3802 View all products for this Gene ID 3810 View all products for this Gene ID 3808 View all products for this Gene ID 3806 View all products for this Gene ID
UniProt
View information about CD158 on UniProt.org

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