APC/Fire™ 750 anti-human CD158 (KIR2DL1/S1/S-上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 2112	1

Product Details

Verified Reactivity

Human

Reported Reactivity

Baboon, Cynomolgus

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Human NK cell clone LB2

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography and conjugated with APC/Fire? 750 under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L per million cells in 100 ?L staining volume or 5 ?L per 100 ?L of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

* APC/Fire? 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.

Excitation Laser

Red Laser (633 nm)

Application Notes

mAb HP-MA4 reacts with KIR2DL1 (CD158a), KIR2DS1 (CD158h), KIR2DS3, and KIR2DS5 (CD158g).

Additional reported applications include: inhibits NK cell mediated cytotoxicity and immunoprecipitation.

This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).

Application References (PubMed link indicates BioLegend citation)

De Miguel M and M. Lopez-Botet. 2002. Inmunologia. 21:187
Goodridge JP, et al. 2013. J. Immunol. 191:3553. PubMed

RRID

AB_2832663 (BioLegend Cat. No. 339519) AB_2832664 (BioLegend Cat. No. 339520)

Antigen Details

Structure: Contains two Ig-like extracellular domains, 58/50 kD
Distribution: Subset of NK cells and a small subset of CD8+ T cells
Function: Inhibits NK cell function, play a role in self-tolerance.
Ligand/Receptor: HLA-C
Cell Type: NK cells, T cells
Biology Area: Immunology, Inhibitory Molecules
Molecular Family: CD Molecules
Antigen References: 1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
Gene ID: 3802 View all products for this Gene ID 3810 View all products for this Gene ID 3808 View all products for this Gene ID 3806 View all products for this Gene ID
UniProt: View information about CD158 on UniProt.org

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