Purified anti-human CD57 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 1632	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Membrane extract of human lymphoblastoid cell line HSB-2.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
IHC-P - Verified
WB - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume.?For immunohistochemistry, a concentration range of 5.0 - 10.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications for the relevant formats include: Western blotting¹.

Application References (PubMed link indicates BioLegend citation)

Yoshihara Y, et al. 1991. J. Cell Biol. 115:731. (WB)
Abo T, et al. 1981. J. Immunol. 127:1024.
Abo T, et al. 1982. J. Immunol. 129:1752.
Abo T, et al. 1982. J. Immunol. 129:1758.

Product Citations

Arunachalam PS, et al. 2021. Nature. 596:410. PubMed
Neidleman J, et al. 2020. Elife. 9:00. PubMed
Neidleman J, et al. 2020. Cell Rep Med. 100081:1. PubMed
Syrimi E, et al. 2021. iScience. 24:103215. PubMed
Neidleman J, et al. 2021. Elife. 10:. PubMed
Neidleman J, et al. 2021. Cell Rep. 36:109414. PubMed
Xie G, et al. 2021. Cell Reports. 35(4):109038. PubMed
Martin E, et al. 2020. JCI Insight. :5. PubMed

RRID

AB_2562403 (BioLegend Cat. No. 359602)

Antigen Details

Structure: Oligosaccharide antigenic determinant present on a variety of proteins, lipids, and chrondroitin sulfate proteoglycans, 100-115 kD. The antigen is conserved across species.
Distribution: CD57 antigen is expressed on a subset of peripheral blood lymphocytes including a subset of NK cells and a subset of CD8⁺ T cells. Also expressed on neural cells and striated muscle.
Function: Unknown function, may be involved in cell-matrix interactions.
Ligand/Receptor: Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment.
Cell Type: Lymphocytes, NK cells, T cells
Biology Area: Costimulatory Molecules, Immunology
Molecular Family: CD Molecules
Antigen References: 1. Schubert J, et al. 1989. In Leucocyte Typing IV (Knapp W, ed) Oxford University Press Oxford pp 711-714.
2. Palmer BE, et al. 2005. J. Immunol. 175:8415.
3. Schachner M, et al. 1995. Trends Neurosci. 18:183.
4. Wood KL, et al. 2005. Clin. Immunol. 117:294.
Gene ID: 27087 View all products for this Gene ID
UniProt: View information about CD57 on UniProt.org

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