Alexa Fluor® 594 anti-human CD57 Antibody
- 产品名称：
- Alexa Fluor® 594 anti-human CD57 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 359625
- 产品应用：
- 359625
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Membrane extract of human lymphoblastoid cell line HSB-2.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 594 under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor? 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Application Notes
Additional reported applications for the relevant formats include: Western blotting1.
- Application References
(PubMed link indicates BioLegend citation) -
- Yoshihara Y, et al. 1991. J. Cell Biol. 115:731. (WB)
- Abo T, et al. 1981. J. Immunol. 127:1024.
- Abo T, et al. 1982. J. Immunol. 129:1752.
- Abo T, et al. 1982. J. Immunol. 129:1758.
- RRID
- AB_2749946 (BioLegend Cat. No. 359625) AB_2749947 (BioLegend Cat. No. 359626)
- Structure
- Oligosaccharide antigenic determinant present on a variety of proteins, lipids, and chrondroitin sulfate proteoglycans, 100-115 kD. The antigen is conserved across species.
- Distribution
-
CD57 antigen is expressed on a subset of peripheral blood lymphocytes including a subset of NK cells and a subset of CD8+ T cells. Also expressed on neural cells and striated muscle.
- Function
- Unknown function, may be involved in cell-matrix interactions.
- Ligand/Receptor
- Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment.
- Cell Type
- Lymphocytes, NK cells, T cells
- Biology Area
- Immunology, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
-
1. Schubert J, et al. 1989. In Leucocyte Typing IV (Knapp W, ed) Oxford University Press Oxford pp 711-714.
2. Palmer BE, et al. 2005. J. Immunol. 175:8415.
3. Schachner M, et al. 1995. Trends Neurosci. 18:183.
4. Wood KL, et al. 2005. Clin. Immunol. 117:294.
- Gene ID
- 27087 View all products for this Gene ID
- UniProt
- View information about CD57 on UniProt.org
