PE anti-mouse Notch 1 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
50µg	￥ 2196	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Armenian Hamster

Immunogen

Notch1-Fc fusion protein

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.

Concentration

0.2 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 10⁶ cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application References (PubMed link indicates BioLegend citation)

Moriyama Y, et al. 2008. Int. Immunol. 20:763.

Product Citations

Kakuda S, et al. 2020. J Biol Chem. 295:14710. PubMed
Hirano KI, et al. 2021. eLife. 0.416666666666667. PubMed
Liu X, et al. 2021. eLife. 0.416666666666667. PubMed
Romero-Wolf M, et al. 2020. J Cell Biol. :219. PubMed
Fermino M, et al. 2013. Eur J Immunol. 43:1806. PubMed
Hombrink P, et al. 2016. Nat Immunol. 17:1467-1478. PubMed

RRID

AB_1227719 (BioLegend Cat. No. 130607) AB_2153356 (BioLegend Cat. No. 130608)

Antigen Details

Structure: Transmembrane receptor. Heterodimer consisting of a C-terminal fragment and N-terminal fragment probably linked by disulphide bonds. Contains 5 ankyrin repeats, 29-36 EGF repeats, 3 Notch/Lin repeats.
Distribution: Highly expressed in the brain, lung, and thymus (CD4-CD8- cells and CD4-CD8+ cells). Lower levels of expression in spleen, bone marrow, spinal cord, eyes, mammary gland, liver, intestine, kidney, and heart.
Function: Regulates broad spectrum of various cell lineage commitment processes, including myogenesis, neurogenesis, gliogenesis, and lymphocyte development.
Ligand/Receptor: Jag 1,2; Delta 1,2
Cell Type: Neural Stem Cells
Biology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells, Synaptic Biology
Molecular Family: Postsynaptic proteins
Antigen References: 1. Ehebauer ME, et al. 2006. Biochem. J. 392:13.
2. Shimizu K, et al. 2000. Mol. Cell. Biol. 20:18.
3. Tanigaki K, et al. 2007. Nature Immunol. 8:4514.
4. Kraman M, et al. 2005. FASEB J. 19:1311.
Gene ID: 18128 View all products for this Gene ID
UniProt: View information about Notch 1 on UniProt.org

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