Purified anti-mouse Jagged 2 Antibody
- 产品名称：
- Purified anti-mouse Jagged 2 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 131001
- 产品应用：
- 131001
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- CHO cells expressing murine Jagged-2
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IHC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Moriyama Y, et al. 2008. Int. Immunol. 20:763 (FC)
- Product Citations
-
- Sharma VP, et al. 2021. Nat Commun. 12:7300. PubMed
- RRID
- AB_1227682 (BioLegend Cat. No. 131001)
- Structure
- A single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). After a single transmembrane domain (TM) is a short in
- Distribution
- Testicular tissues and spermatids
- Function
- The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell development, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect the target cells. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate.
- Ligand/Receptor
- Notch receptors
- Cell Targets
- Skeletrophin binds the intracellular regions of Jagged-2, but not those of Delta-1,3,4, or Jagged-1.
- Biology Area
- Immunology
- Antigen References
-
1. Ehebauer MT, et al. 2006. Biochem J 392:13
2. Shimizu K, et al. 2000. Mol Cell Biology 20:18
3. Hellstrom M, et al. 2007. Nature 445:776
4. Luo B, et al. 1997. Mol Cell Biol. 17:6057
- Gene ID
- 16450 View all products for this Gene ID
- UniProt
- View information about Jagged 2 on UniProt.org
