APC anti-mouse CD339 (Jagged 1) Antibody
- 产品名称：
- APC anti-mouse CD339 (Jagged 1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 130913
- 产品应用：
- 130913
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- Murine Jagged 1-Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: in vivo blocking of Jagged 1 in EAE1 and immunohistochemical staining of frozen spleen sections2.
- Application References
(PubMed link indicates BioLegend citation) -
- Elyaman W, et al. 2007. J. Immunol. 179:5990. (Block)
- Sekine C, et al. 2009. Int. Immunol. 21:295. (IHC)
- Product Citations
-
- Menzel L, et al. 2021. Cell Rep. 37:109878. PubMed
- Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
- Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
- RRID
- AB_2561304 (BioLegend Cat. No. 130913) AB_2561305 (BioLegend Cat. No. 130914)
- Structure
- Type 1 transmembrane protein, 1 DSL (Delta, Serrate, LagZ) domain, 15 EGF-like domains, 1 cystein riche region; 135 kD
- Distribution
-
Macrophages, subsets of dendritic cells, stromal cells, epithelial cells, astrocytes
- Function
- Regulates cell fate decisions in various tissues, important role in cardiovascular system development, neurogenesis, and T cell polarization to Th2 lineage
- Ligand/Receptor
- Notch1, Notch2, Notch3
- Cell Type
- Astrocytes, Dendritic cells, Epithelial cells, Macrophages
- Biology Area
- Angiogenesis, Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Amsen D, et al. 2004. Cell. 117:515.
2. Cheng P, et al. 2007. Blood. 109: 507.?
3. Goh F, et al. 2009. Immunology. 127:326.?
4. Zeng H, et al. 2012. PLoS One. 7:e35905.
- Gene ID
- 16449 View all products for this Gene ID
- UniProt
- View information about CD339 on UniProt.org
