Purified anti-mouse DLL4 Antibody
- 产品名称：
- Purified anti-mouse DLL4 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 130802
- 产品应用：
- 130802
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- CHO cells expressing murine DLL4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
Block -?Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Wei Y, et al. 2013. PNAS. 110:3910. PubMed?(Block)
- Product Citations
-
- Koyanagi A, et al. 2012. Biochem Biophys Res Commun. 418:799. PubMed
- Zwick M, et al. 2019. Front Immunol. 10:222. PubMed
- Wei Y, et al. 2013. Proc Natl Acad Sci U S A. 110:3910. PubMed
- Jang S, et al. 2010. J Immunol. 185:5835. PubMed
- RRID
- AB_1227639 (BioLegend Cat. No. 130802)
- Structure
- A single-pass transmembrane (TM) protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs). After the single TM domain is a novel intracellular domain.
- Distribution
-
DLL4 is primarily expressed in arterial blood vessels and sprouting endothelial cells. DLL4 is also expressed in thymic epithelial cells.
- Function
- The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate of various cell's development, including myogenesis, neurogenesis, and lymphocyte development.
- Ligand/Receptor
- Notch Receptors
- Cell Type
- Endothelial cells, Epithelial cells
- Biology Area
- Immunology
- Antigen References
-
1. Ehebauer MT, et al. 2006. Biochem J. 392:13.
2. Shimizu K, et al. 2000. Mol Cell Biol. 20:6913.
3. Hellstrom M, et al. 2007. Nature 445:776.
4. Suchting S, et al. 2007. P. Natl. Acad. Sci. USA 104:3225.
- Gene ID
- 54485 View all products for this Gene ID
- UniProt
- View information about Delta-like 4 on UniProt.org
