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Pacific Blue™ anti-mouse CD48 Antibody
产品名称：
Pacific Blue™ anti-mouse CD48 Antibody
产品类别：
抗体
产品编号：
103417
产品应用：
103417
[价格]
规格 价格 库存
25µg ￥ 1212 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse T lymphoma MBL-2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with Pacific Blue? under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Pacific Blue? has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue? conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.


Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

View full statement regarding label licenses
Excitation Laser
Violet Laser (405 nm)
Application Notes

The HM48-1 antibody is useful for blocking in vitro and in vivo CD48 mediated interactions. Additional reported applications (for the relevant formats) include: immunoprecipitation1, costimulation of T cell proliferation1,2, blocking of CD48-CD2 interaction1, and inhibition of CTL activity and graft rejection1,2. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. Nos. 103452-103456) with a lower endotoxin limit (Endotoxin < 0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Kato K, et al. 1992. J. Exp. Med. 176:1241. (IP, Costim, Block)
  2. Qin L, et al. 1994. J. Exp. Med. 179:341. (Costim, Block)
Product Citations
  1. Florentin J, et al. 2022. Front Immunol. 13:882484. PubMed
  2. Sch?nberger K, et al. 2022. Cell Stem Cell. 29:131. PubMed
  3. Zhang B, et al. 2018. Nat Med. 24:450. PubMed
  4. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  5. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  6. Zhao M, et al. 2019. Cell Rep. 26:652. PubMed
  7. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  8. Kang H, et al. 2012. J Immunol. 188:5970. PubMed
  9. MacNamara K, et al. 2011. PLoS One. 6:e28669. PubMed
  10. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  11. Cabezas–Wallscheid N, et al. 2017. Cell. 169:807. PubMed
  12. Charmsaz S, et al. 2015. PLoS One. 10:130692. PubMed
  13. Grassinger J, et al. 2012. Cytokine. 58:218. PubMed
  14. Dong S, et al. 2021. Nature. 591:117. PubMed
  15. Nacson J, et al. 2020. Molecular Cell. 78(5):951-959. PubMed
  16. Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
  17. Sauer A, et al. 2009. Blood. 114:3216. PubMed
  18. Vasamsetti SB, et al. 2018. Immunity. 49:93. PubMed
  19. Omatsu Y, et al. 2022. Nat Commun. 13:2654. PubMed
  20. Nestorowa S, et al. 2016. Blood. 128: e20 - e31. PubMed
  21. Park DS, et al. 2019. PLoS Comput Biol. 15:e1006913. PubMed
  22. Morganti C, et al. 2022. EMBO Rep. 23:e54262. PubMed
  23. Riedel SS, et al. 2021. Molecular Cell. 81(11):2332-2348.e9. PubMed
  24. Wilkinson AC, et al. 2019. Nature. 571:117. PubMed
  25. Li X, et al. 2019. Stem Cells. 37:937. PubMed
  26. Vannini N, et al. 2016. Nat Commun. 7:13125. PubMed
  27. Kang YA, et al. 2020. J Exp Med. 217:00:00. PubMed
  28. Man N, et al. 2021. JCI Insight. 6:. PubMed
RRID
AB_756139 (BioLegend Cat. No. 103417) AB_756140 (BioLegend Cat. No. 103418)

Antigen Details

Structure
Ig superfamily, 45 kD
Distribution

T cells and B cells, monocytes/macrophages

Function
Adhesion, T cell recognition
Ligand/Receptor
CD2, CD244
Cell Type
B cells, Macrophages, Monocytes, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Flament C, et al. 1996. Hum. Immunol. 46:82.
3. Van der Merwe PA, et al. 1995. Curr. Biol. 5:74.
4. Latchman Y, et al. 1998. J. Immunol. 161:5809.

Gene ID
12506 View all products for this Gene ID
UniProt
View information about CD48 on UniProt.org

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