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Brilliant Violet 421™ anti-mouse CD48 Antibo
产品名称：
Brilliant Violet 421™ anti-mouse CD48 Antibo
产品类别：
抗体
产品编号：
103427
产品应用：
103427
[价格]
规格 价格 库存
125µL ￥ 2184 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse T lymphoma MBL-2
Formulation
?l size: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
?g size: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
Concentration
?g size: 0.2 mg/mL
?L size: lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining using the ?l size, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood. For flow cytometric staining using the ?g size, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

The HM48-1 antibody is useful for blocking in vitro and in vivo CD48 mediated interactions. Additional reported applications (for the relevant formats) include: immunoprecipitation1, costimulation of T cell proliferation1,2, blocking of CD48-CD2 interaction1, and inhibition of CTL activity and graft rejection1,2. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. Nos. 103452-103456) with a lower endotoxin limit (Endotoxin < 0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Kato K, et al. 1992. J. Exp. Med. 176:1241. (IP, Costim, Block)
  2. Qin L, et al. 1994. J. Exp. Med. 179:341. (Costim, Block)
Product Citations
  1. Sch?nberger K, et al. 2022. Cell Stem Cell. 29:131. PubMed
  2. Stratigou V, et al. 2017. Rheumatology. 10.1093/rheumatology/kex078. PubMed
  3. Delás MJ, et al. 2019. Cell Rep. 27:719. PubMed
  4. Fujino T, et al. 2021. Nat Commun. 12:1826. PubMed
  5. Yamamoto K, et al. 2021. Cell Reports. 36(8):109576. PubMed
  6. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  7. Thoms J, et al. 2016. Mol Cell Biol. 36: 1222-1236. PubMed
  8. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  9. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  10. Nosho S, et al. 2020. Int J Mol Sci. 21:00. PubMed
  11. Sch?nberger K, et al. 2022. STAR Protoc. 3:101408. PubMed
  12. Xu C, et al. 2020. Immunity. 53(2):417-428.e4. PubMed
  13. Xu C, et al. 2018. Nat Commun. 9:2449. PubMed
  14. Rodríguez L, et al. 2021. Biomolecules. 11: . PubMed
  15. Rossi G, et al. 2022. Sci Rep. 12:13380. PubMed
RRID
AB_10895922 (BioLegend Cat. No. 103427) AB_2650894 (BioLegend Cat. No. 103428)

Antigen Details

Structure
Ig superfamily, 45 kD
Distribution

T cells and B cells, monocytes/macrophages

Function
Adhesion, T cell recognition
Ligand/Receptor
CD2, CD244
Cell Type
B cells, Macrophages, Monocytes, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Flament C, et al. 1996. Hum. Immunol. 46:82.
3. Van der Merwe PA, et al. 1995. Curr. Biol. 5:74.
4. Latchman Y, et al. 1998. J. Immunol. 161:5809.

Gene ID
12506 View all products for this Gene ID
UniProt
View information about CD48 on UniProt.org

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