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APC anti-mouse CD48 Antibody
产品名称：
APC anti-mouse CD48 Antibody
产品类别：
抗体
产品编号：
103411
产品应用：
103411
[价格]
规格 价格 库存
25µg ￥ 1224 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse T lymphoma MBL-2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

The HM48-1 antibody is useful for blocking in vitro and in vivo CD48 mediated interactions. Additional reported applications (for the relevant formats) include: immunoprecipitation1, costimulation of T cell proliferation1,2, blocking of CD48-CD2 interaction1, and inhibition of CTL activity and graft rejection1,2. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. Nos. 103452-103456) with a lower endotoxin limit (Endotoxin < 0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Kato K, et al. 1992. J. Exp. Med. 176:1241. (IP, Costim, Block)
  2. Qin L, et al. 1994. J. Exp. Med. 179:341. (Costim, Block)
Product Citations
  1. Grigsby SM, et al. 2021. Cancers (Basel). 13:. PubMed
  2. Bae J, et al. 2019. Nat Commun. 10:3496. PubMed
  3. Tober J, et al. 2020. The Journal of Experimental Medicine. 215(2):645-659. PubMed
  4. Grinenko T, et al. 2018. Nat Commun. 9:1898. PubMed
  5. Stivala S, et al. 2019. J Clin Invest. 130:1596. PubMed
  6. Lopez DA, et al. 2022. Cell Rep. 41:111677. PubMed
  7. Jia W, et al. 2021. Nat Commun. 12:2118. PubMed
  8. Di Genua C, et al. 2020. Cancer Cell. 37(5):690-704.e8.. PubMed
  9. Yu VWC, et al. 2017. Cell. 168:944. PubMed
  10. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  11. Li Y, et al. 2020. Cell Stem Cell. 27(5):732-747.e7. PubMed
  12. Comazzetto S et al. 2018. Cell stem cell. 24(3):477-486 . PubMed
  13. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  14. Yankova E, et al. 2021. Nature. 593:597. PubMed
  15. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  16. Fontinha D, et al. 2015. PLoS One. 10: 0142540. PubMed
  17. Booth CAG, et al. 2018. Cancer Cell. 33:274. PubMed
  18. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  19. Maetzig T, et al. 2017. Mol Ther. 25:606. PubMed
  20. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  21. Murakami K, et al. 2021. Cell Reports. 34(1):108579. PubMed
  22. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  23. Chen R, et al. 2021. Cell Reports. 34(7):108751. PubMed
  24. Hoffmann J, et al. 2021. Nat Commun. 12:3964. PubMed
  25. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  26. Koide S, et al. 2022. iScience. 25:103603. PubMed
  27. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  28. Zhang Y, et al. 2016. Sci Rep. 6:37827. PubMed
  29. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  30. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  31. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  32. Young K, et al. 2021. Cell Stem Cell. . PubMed
RRID
AB_571996 (BioLegend Cat. No. 103411) AB_571997 (BioLegend Cat. No. 103412)

Antigen Details

Structure
Ig superfamily, 45 kD
Distribution

T cells and B cells, monocytes/macrophages

Function
Adhesion, T cell recognition
Ligand/Receptor
CD2, CD244
Cell Type
B cells, Macrophages, Monocytes, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Flament C, et al. 1996. Hum. Immunol. 46:82.
3. Van der Merwe PA, et al. 1995. Curr. Biol. 5:74.
4. Latchman Y, et al. 1998. J. Immunol. 161:5809.

Gene ID
12506 View all products for this Gene ID
UniProt
View information about CD48 on UniProt.org

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