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Brilliant Violet 711™ anti-mouse Ly-6C Antib
产品名称：
Brilliant Violet 711™ anti-mouse Ly-6C Antib
产品类别：
抗体
产品编号：
128037
产品应用：
128037
[价格]
规格 价格 库存
50µg ￥ 3432 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
L3 cloned CTL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711? under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume or 100 ?l of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 711? excites at 405 nm and emits at 711 nm. The bandpass filter 710/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 711? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

Clone HK1.4 does not block the binding of clone RB6-8C58.

Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells1-3 and immunohistochemistry of frozen sections4.

Application References

(PubMed link indicates BioLegend citation)
  1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819. (Activ)
  2. Herold KC, et al. 1990. Diabetes 39:815. (Activ)
  3. Havran WL, et al. 1988. J. Immunol. 140:1034 (Activ)
  4. Flanagan K, et al. 2008. J. Immunol. 180:3874. (IHC)
  5. Makaroff LE, et al. 2009. P. Natl. Acad. Sci. USA 106:4799. (FC)
  6. Zuber J, et al. 2009. Genes Dev. 23:877. (FC) PubMed
  7. Ribechini E, et al. 2009. Eur. J. Immunol. 39:3538.
  8. Ma C, et al. 2012. J. Leukoc. Biol. 92:1199.
  9. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
Product Citations
  1. Argüello RJ, et al. 2020. Cell Metab. 32:1063. PubMed
  2. Komuczki J, et al. 2019. Immunity. 50:1289. PubMed
  3. Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
  4. Hagan N, et al. 2020. Cell Death Dis. 1.086111111. PubMed
  5. Hu W, et al. 2021. Nat Immunol. 22:1163. PubMed
  6. Barry KC, et al. 2018. Nat Med. 24:1178. PubMed
  7. Chattopadhyay A, et al. 2018. Sci Rep. 8:9032. PubMed
  8. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  9. Zhu B, et al. 2021. Immunity. 54(6):1200-1218.e9. PubMed
  10. Bhattacherjee A, et al. 2021. Mol Neurodegener. 16:19. PubMed
  11. Ostendorf BN, et al. 2020. Nat Med. 26:1048. PubMed
  12. Bhattacherjee A, et al. 2019. Commun Biol. 2:450. PubMed
  13. Jenkins RW, et al. 2018. Cancer Discov. 8:196. PubMed
  14. Liang Z, et al. 2020. Pain. 161:2089. PubMed
  15. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  16. Dikiy S, et al. 2021. Immunity. 54(5):931-946.e11. PubMed
  17. Goldman E, et al. 2021. Cells. 10:. PubMed
  18. Ruhland MK, et al. 2020. Cancer Cell. 37(6):786-799.e5. PubMed
  19. Kelsey E Sivick et al. 2018. Cell reports. 25(11):3074-3085 . PubMed
  20. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  21. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  22. Koivisto CS, et al. 2020. Neoplasia. 1.252777778. PubMed
  23. Salvioni A et al. 2019. Cell Rep. 27(11):3254-3268 . PubMed
  24. Kennedy EM, et al. 2022. Nat Commun. 13:5907. PubMed
  25. Brandi P, et al. 2022. Cell Rep. 38:110184. PubMed
  26. Brown CC, et al. 2020. Cell. 179(4):846-863.e24.. PubMed
  27. Tavazoie MF, et al. 2018. Cell. 172:825. PubMed
  28. Campbell C et al. 2018. Immunity. 48(6):1245-1257 . PubMed
  29. Krueger A, et al. 2022. Front Microbiol. 12:789042. PubMed
  30. Van Winkle JA et al. 2018. Cell host & microbe. 24(5):665-676 . PubMed
  31. Kar S, Colino J, Snapper C 2016. J Immunol. 196: 4204 - 4213. PubMed
  32. Tummers B, et al. 2020. Immunity. 52(6):994-1006.e8. PubMed
  33. Beura LK, et al. 2018. Immunity. 48:327. PubMed
  34. Sakamoto K, et al. 2021. Immunity. 54:2321. PubMed
  35. Abdelfattah N, et al. 2022. Nat Commun. 13:767. PubMed
  36. Pizzurro GA, et al. 2021. Cancers (Basel). 13:. PubMed
  37. Chitu V, et al. 2020. Cell Reports. 30(9):3004-3019. PubMed
  38. Xueyang Yu et al. 2017. Immunity. 47(5):903-912 . PubMed
  39. Montalban-Arques A, et al. 2021. Cell Host Microbe. :. PubMed
  40. Mujal AM, et al. 2022. Cancer Immunol Res. 10:403. PubMed
  41. Hering L, et al. 2020. Front Immunol. 1.747222222. PubMed
  42. Sakamoto K, et al. 2022. STAR Protoc. 3:101052. PubMed
  43. Maller O, et al. 2020. Nat Mater. 20:548. PubMed
  44. Zhang L, et al. 2020. Cell. 442:181. PubMed
  45. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  46. O'Boyle C, et al. 2020. Int J Stroke. 0.746527778. PubMed
  47. Pastor Arroyo EM, et al. 2022. Clin Sci (Lond). 136:557. PubMed
  48. Ichinose M, et al. 2021. Sci Rep. 7200:11. PubMed
RRID
AB_2562630 (BioLegend Cat. No. 128037)

Antigen Details

Structure
14-17 kD protein (134 amino acids), member of the Ly-6 family of GPI linked protein. Ly6 family members share structure homology throughout a distinctive cystein rich protein domain that incorporates O-linked carbohydrates.
Distribution

Ly-6C is expressed primarily on bone marrow myeloid populations, monocytes/macrophages, neutrophils, endothelial cells, and some T cell subsets. Ly-6C is also a marker of memory CD8+ T cells.

Cell Type
Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819.
2. Cerwenka A, et al. 1998. J. Immunol. 161:97.

Gene ID
17067 View all products for this Gene ID
UniProt
View information about Ly-6C on UniProt.org

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