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APC/Cyanine7 anti-human CD45 Antibody
产品名称：
APC/Cyanine7 anti-human CD45 Antibody
产品类别：
抗体
产品编号：
304014
产品应用：
304014
[价格]
规格 价格 库存
100tests ￥ 3504 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC/Cyanine7 under optimal conditions.
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissue sections9, inhibition of CD45 functions4, immunofluorescence11,?Western blotting3, and spatial biology (IBEX)16,17.

It was found that the HI30 clone and the 2D1 clone can cross block each other's binding.

Additional Product Notes
BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  2. Kishihara K, et al. 1993. Cell 74:143.
  3. Esser M, et al. 2001. J. Virol. 75:6173. (WB)
  4. Yamada T, et al. 2002. J. Biol. Chem. 277:28830.
  5. Nagano M, et al. 2007. Blood 110:151.
  6. Jiang Q, et al. 2008. Blood 112:2858. PubMed
  7. Morozov A, et al. 2010. Clin Cancer Res. 16:5630. PubMed
  8. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  9. Friedman T, et al. 1999. J. Immunol. 162:5256. (IHC)
  10. Oeztuerk-Winder F, et al. 2012. EMBO J. 31:3431. (FC) PubMed
  11. Rees LE, et al. 2003. Clin. Exp. Immunol. 134:497. (IF)
  12. Lee J, et al. 2015. J Exp Med. 212:385. PubMed
  13. Breton G, et al. 2015. J Exp Med. 212:401. PubMed
  14. Marquardt N, et al. 2015. J Immunol. 6:2467. PubMed
  15. Bushway ME, et al. 2014. Biol Reprod. 90(5): 110. (IF) PubMed
  16. Radtke AJ,?et al. 2020.?Proc Natl Acad Sci USA. 117:33455-33465. (SB)?PubMed
  17. Radtke AJ,?et al. 2022.?Nat Protoc. 17:378-401. (SB)?PubMed
Product Citations
  1. Wang X, et al. 2019. Cell Res. 29:787. PubMed
  2. Li M, et al. 2021. J Clin Invest. 131:. PubMed
  3. Qiu J, et al. 2020. Cell Rep. 33:108465. PubMed
  4. Ryzhov S, et al. 2019. J Am Heart Assoc. 8:e010874. PubMed
  5. Zong D, et al. 2021. BMC Biol. 19:79. PubMed
  6. Ahmed R et al. 2019. Cell. 177(6):1583-1599 . PubMed
  7. Aghajani Nargesi A, et al. 2019. Stem Cell Rev Rep. 0.921527778. PubMed
  8. Cheng L, et al. 2021. Cancer Immunol Immunother. Online ahead of print. PubMed
  9. Yang C, et al. 2021. J Immunother Cancer. 9:. PubMed
  10. Zhao Y, et al. 2021. Front Immunol. 12:665442. PubMed
  11. Thomas A, et al. 2021. Cancer Cell. 39(4):566-579.e7. PubMed
  12. V Faivre, A Lukaszewicz, D Payen 2016. PLoS One. 11:e0164489. PubMed
  13. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  14. Ma L, et al. 2021. Clinical Cancer Research. 27(6):1778-1791. PubMed
  15. Noel S, et al. 2015. J Am Soc Nephrol. 101681/ASN2014100978. PubMed
  16. Blatt K, et al. 2014. Clin Cancer Res. 20:3589. PubMed
  17. Huang B, et al. 2020. Cell. 179(5):1160-1176.e24.. PubMed
  18. Kathiriya JJ, et al. 2022. Nat Cell Biol. 24:10. PubMed
  19. Xu L, et al. 2022. Front Oncol. 12:967982. PubMed
  20. Hornburg M, et al. 2021. Cancer Cell. . PubMed
  21. Ping Y, et al. 2020. Front Cell Dev Biol. 0.890972222. PubMed
  22. Hurrell BP, et al. 2019. Cell Rep. 29:4509. PubMed
  23. Holstein M, et al. 2018. Mol Ther. 26:1137. PubMed
  24. Rochman M, et al. 2022. JCI Insight. 7:. PubMed
  25. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  26. Yin W, et al. 2021. Thorac Cancer. 12:2680. PubMed
  27. Yuan Z, et al. 2018. Emerg Microbes Infect. 7:59. PubMed
  28. Pearson JM, et al. 2020. Molecular Cancer Research. 18(3):352-363. PubMed
  29. Ugawa M, et al. 2021. Elife. 10:. PubMed
  30. Leone D, et al. 2016. PLoS One. 11: 0151674. PubMed
  31. Singh N, et al. 2017. J Endocrinol. 235:69. PubMed
  32. Tripathi H, et al. 2020. Stem Cell Rev Rep. 0.953472222. PubMed
  33. Li G, et al. 2019. J Virol. 93:e00233-19. PubMed
  34. Worthen CA, et al. 2020. J Invest Dermatol. 140:2515. PubMed
  35. Wei C, et al. 2016. Cell Death Dis. 7:e2489. PubMed
  36. Wang L, et al. 2014. Proc Natl Acad Sci U S A. 111:3146. PubMed
  37. Annageldiyev C, et al. 2019. Haematologica. 10.3324/haematol.2018.212886. PubMed
  38. Shafiei-Jahani P, et al. 2021. Nat Commun. 12:2526. PubMed
  39. Mori A, et al. 2021. Cells. :10. PubMed
  40. Galle-Treger L, et al. 2019. Nat Commun. 10:713. PubMed
  41. Le J, et al. 2020. Immunity. 52(6):1105-1118.e9. PubMed
  42. Diaz M, et al. 2017. Stem Cells. 10.1002/stem.2587. PubMed
  43. Lee YS, et al. 2021. J Immunother Cancer. 9:. PubMed
  44. Duinhouwer L, et al. 2015. PLoS One. 10:119086. PubMed
  45. Meziane O, et al. 2020. J Virol. 94:00:00. PubMed
  46. Mesa-Nu?ez C, et al. 2020. Stem Cell Res Ther. 11:164. PubMed
  47. Pham TNQ, et al. 2020. Cell Reports. 29(9):2770-2782.e5.. PubMed
  48. Novak R, et al. 2022. Cell Death Dis. 13:820. PubMed
  49. Namkoong H, et al. 2018. PLoS Pathog. 14:e1006955. PubMed
  50. Mathewson ND, et al. 2021. Cell. 184(5):1281-1298.e26. PubMed
  51. Crinier A, et al. 2018. Immunity. 49:971. PubMed
  52. Román-Rodriguez FJ, et al. 2019. Cell Stem Cell. 25:607. PubMed
  53. Zhao Y, et al. 2020. Front Immunol. 2.572222222. PubMed
  54. Cai T, et al. 2022. Nat Commun. 13:2228. PubMed
  55. Mesa-Nu?ez C, et al. 2022. Mol Ther Methods Clin Dev. 26:459. PubMed
  56. Bharat A, et al. 2020. Science Translational Medicine. 12(574):. PubMed
  57. Tomita T, et al. 2021. Nat Commun. 12:3655. PubMed
  58. Yang Z, et al. 2022. Transl Androl Urol. 11:803. PubMed
  59. Alhaj Hussen K, et al. 2020. Front Immunol. 11:579776. PubMed
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RRID
AB_314402 (BioLegend Cat. No. 304014)

Antigen Details

Structure
Tyrosine phosphatases, type I transmembrane protein, 180-240 kD (multiple isoforms)
Distribution

Hematopoietic cells, not expressed in circulating erythrocytes or platelets

Function
TCR and BCR mediated activation
Ligand/Receptor
Galectin-1, CD2, CD3, CD4
Cell Type
Hematopoietic stem and progenitors, Mesenchymal Stem Cells
Biology Area
Cell Biology, Immunology, Inhibitory Molecules, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules
Antigen References
  1. Thomas M. 1989. Annu. Rev. Immunol. 7:339.
  2. Trowbridge I, et al. 1994. Annu. Rev. Immunol.12:85.
Gene ID
5788 View all products for this Gene ID
UniProt
View information about CD45 on UniProt.org

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